Evidence map›Paper›PMID 41484707›Full record

ArticleBMC infectious diseases2026

A rare case of peritoneal dialysis-associated peritonitis caused by Coxiella burnetii diagnosed by mNGS.

Zijuan Zhou, Xixi Zheng, Wei Yang, Ying Cui, Yingying Gao, Jinghua Xia, Yao Wang, Yi Gao, Minya Lu, Dong Zhang and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zijuan Zhou *Nephrology Department, Peking Union Medical College Hospital, Beijing, China.
Xixi Zheng *Nephrology Department, Peking Union Medical College Hospital, Beijing, China.
Wei YangNephrology Department, Peking Union Medical College Hospital, Beijing, China.
Ying CuiNephrology Department, Peking Union Medical College Hospital, Beijing, China.
Yingying GaoNephrology Department, Peking Union Medical College Hospital, Beijing, China.
Jinghua XiaNephrology Department, Peking Union Medical College Hospital, Beijing, China.
Yao WangDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Yi GaoDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Minya LuDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Dong ZhangDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Haiyun WangNephrology Department, Peking Union Medical College Hospital, Beijing, China. wanghaiyun62926@126.com.
Limeng ChenNephrology Department, Peking Union Medical College Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a rare case of peritoneal dialysis (PD)-associated peritonitis caused by Coxiella burnetii, an intracellular pathogen typically associated with Q fever. A 28-year-old female with lupus nephritis and end-stage kidney disease on PD presented with cloudy effluent and abdominal pain after consuming undercooked lamb. Despite initial empirical broad-spectrum antibiotic therapy (cefazolin/ceftazidime protocol), clinical symptoms persisted. Conventional bacterial, fungal, and mycobacterial cultures were negative. Metagenomic next-generation sequencing (mNGS) of the peritoneal effluent identified C. burnetii DNA. The treatment was transitioned to doxycycline and hydroxychloroquine resulted in clinical improvement and normalization of inflammatory markers. This case underscores the diagnostic value of mNGS in culture-negative peritonitis and emphasizes C. burnetii as an emerging pathogen in immunocompromised PD patients, particularly with zoonotic exposure histories.

Indexed as

Coxiella burnetiiPeritoneal DialysisPeritonitisQ FeverAdultAnimalsAnti-Bacterial AgentsDoxycyclineFemaleHigh-Throughput Nucleotide SequencingHumansHydroxychloroquineKidney Failure, ChronicAnti-Bacterial AgentsDoxycyclineHydroxychloroquineCoxiella burnetiiCulture-negative peritonitismNGSPeritoneal dialysis-associated-peritonitis

Identifiers

PMID41484707
PMCPMC12865928

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.