Evidence map›Paper›PMID 41484670›Full record

ArticleVeterinary research2026

Host genetics, lung T-cell immunity, and laying activity determine the disease outcome in avian influenza virus-infected chickens.

Luise Freier, Angele Breithaupt, Maryna Kuryshko, Diana I Palme, Steffen Weigend, Elsayed M Abdelwhab, Ulrike Blohm

Abstract read
In one paragraph

Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luise FreierInstitute of Immunology, Friedrich-Loeffler-Institut, Suedufer 10, 17493, Greifswald-Insel Riems, Germany.
Angele BreithauptDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Suedufer 10, 17493, Greifswald-Insel Riems, Germany.
Maryna KuryshkoInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Suedufer 10, 17493, Greifswald-Insel Riems, Germany.
Diana I PalmeInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Suedufer 10, 17493, Greifswald-Insel Riems, Germany.
Steffen WeigendInstitute of Farm Animal Genetics, Friedrich-Loeffler-Institut, Hoeltystrasse 10, 31535, Neustadt, Germany.
Elsayed M AbdelwhabInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Suedufer 10, 17493, Greifswald-Insel Riems, Germany.
Ulrike BlohmInstitute of Immunology, Friedrich-Loeffler-Institut, Suedufer 10, 17493, Greifswald-Insel Riems, Germany. ulrike.blohm@fli.de.

Funding

Federal Office for Agriculture and Food (BLE) FKZ: 2819OE164
6 · The paper itself

Abstract

Avian influenza viruses pose a threat to both wild and domestic bird populations worldwide. In particular, chickens kept outdoors have contact with wild birds and thus an increased risk of infection with influenza viruses. Increasing use of high-performance chicken breeds in growing poultry production reduces genetic diversity whereas local breeds may offer valuable traits such as disease resilience important for sustainable agriculture. This study investigates the immunological performance of three local chicken breeds (Altsteirer, Ramelsloher, and Bielefelder) in Germany to assess their potential resilience to infectious diseases such as avian influenza. Viral resilience was assessed by inoculating 6-week-old chickens with a highly pathogenic avian influenza virus H7N1 and the moderately pathogenic recombinant avian influenza virus TG05-HA

Indexed as

ChickensInfluenza A Virus, H7N1 SubtypeInfluenza in BirdsOvipositionPoultry DiseasesT-LymphocytesAnimalsFemaleGermanyLungViral LoadVirus Sheddingavian influenza viruschickenHost geneticslaying activityT-cell immunity

Identifiers

PMID41484670
PMCPMC12849319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.