ArticleRespiratory research2026
Comprehensive profiling of lactylation-associated genes in pulmonary hypertension through bulk and single-cell RNA sequencing integration.
Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- From Byproduct to Regulator: The Expanding Role of Lactate and Lactylation in Cardiovascular Physiology and Disease.Biology · 2026Review
- Hypoxic Pulmonary Hypertension: Molecular Mechanisms and Clinical Research Advances.International journal of molecular sciences · 2026Review
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8 authors.
Funding
Abstract
backgroundPulmonary hypertension (PH) is a progressive disorder with high pulmonary arterial pressure, causing right ventricular dysfunction. Understanding PH's molecular basis is vital for therapy development, but research on lactylation's role in PH is limited and needs more investigation.
methodsWe integrated bulk RNA-seq datasets (GSE113439, GSE186996) and single-cell RNA-seq data (GSE210248) from PH patients and controls Differential expression analysis identified lactylation-associated hub genes. Functional enrichment (GO/KEGG), immune infiltration, and cell-cell communication analyses were performed. In vitro validation included RT-PCR and western blot on hypoxic pulmonary artery smooth muscle cells (PASMCs).
resultsWe identified lymphocyte cytosolic protein 1 (LCP1) as a core lactylation-related hub gene, significantly upregulated in PH and validated in human/rat models. Single-cell profiling revealed elevated lactylation levels in vascular smooth muscle cells (VSMCs), T lymphocytes, and monocytes/macrophages within PH tissues. Cell communication analysis implicated TWEAK signaling from monocytes/macrophages to VSMCs as a driver of vascular remodeling. Metabolic pathways (e.g., glycolysis, bile acid metabolism) correlated strongly with lactylation activity. In vitro, hypoxia-induced LCP1 overexpression in PASMCs confirmed bioinformatic findings.
conclusionWe analyzed lactylation-related genes in PH, identifying LCP1 as a key diagnostic marker, and described immune cell lactylation in PH patients, offering insights for future research.
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