Evidence map›Paper›PMID 41484606›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026

Measurement of patients' acceptable symptom levels and priorities for symptom improvement in advanced prostate cancer.

Stella Snyder, Ekin Secinti, Ellen F Krueger, Nabil Adra, Roberto Pili, Nasser H Hanna, Catherine E Mosher

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Stella SnyderDepartment of Psychology, Indiana University Indianapolis, 402 North Blackford Street, LD 124, Indianapolis, IN, 46202, USA. stelsnyd@iu.edu.ORCID http://orcid.org/0000-0002-8061-3848
Ekin SecintiDepartment of Psychology, Indiana University Indianapolis, 402 North Blackford Street, LD 124, Indianapolis, IN, 46202, USA.ORCID http://orcid.org/0000-0001-7794-8500
Ellen F KruegerDepartment of Psychology, Indiana University Indianapolis, 402 North Blackford Street, LD 124, Indianapolis, IN, 46202, USA.ORCID http://orcid.org/0000-0003-1553-9175
Nabil AdraDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Roberto PiliDepartment of Medicine, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Nasser H HannaDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Catherine E MosherDepartment of Psychology, Indiana University Indianapolis, 402 North Blackford Street, LD 124, Indianapolis, IN, 46202, USA.ORCID http://orcid.org/0000-0002-9689-5392

Funding

Interdisciplinary Training in Cancer Prevention and ControlT32CA117865 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI Victoria Lee Champion, Catherine E Mosher · 2016 to 2026
$2.4M
National Cancer Institute, United States T32CA117865NCI NIH HHS T32 CA117865Walther Cancer Foundation 0172.01
6 · The paper itself

Abstract

purposeLimited research has evaluated the success criteria and priorities for symptom improvement of patients with cancer to inform patient-centered care. In this study, we adapted and tested a measure of these constructs, the Patient-Centered Outcomes Questionnaire (PCOQ), for patients with advanced prostate cancer. We compared acceptable symptom severity levels following symptom treatment across 10 symptoms and identified patient subgroups based on symptom importance.

methodsPatients with advanced prostate cancer (N = 99) participated in a one-time survey, which included a modified version of the PCOQ, standard symptom measures, and additional clinical characteristics.

resultsThe modified PCOQ demonstrated construct validity through its correlations with related theoretical constructs. There was a moderate correlation between symptom severity and importance. Acceptable symptom severity levels were generally low, with sexual dysfunction having a higher acceptable severity than most other symptoms. Three patient subgroups were identified: (1) those who rated all symptoms as low in importance (n = 43); (2) those who rated all symptoms as moderately important (n = 33); and (3) those who rated all symptoms as highly important (n = 18). Subgroups were associated with functional status, fatigue, sleep problems, pain, and emotional distress.

conclusionThe modified PCOQ demonstrated preliminary evidence of construct validity. Patients generally considered low symptom severity to be acceptable, with variations across symptoms. Results suggest that symptom severity and importance are related but distinct aspects of the symptom experience in advanced prostate cancer. Patients' diverse priorities for symptom improvement point to the need for individualized treatment plans.

Indexed as

Prostatic NeoplasmsAgedAged, 80 and overFatigueHumansMaleMiddle AgedPatient-Centered CarePatient Reported Outcome MeasuresReproducibility of ResultsSeverity of Illness IndexSurveys and QuestionnairesAdvanced prostate cancerLatent profile analysisPatient-centered carePatient-centered outcomesSymptom importanceSymptom severity

Identifiers

PMID41484606
PMCPMC12764673

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.