Evidence map›Paper›PMID 41484560›Full record

ArticleBMC infectious diseases2026

Pre-extensively drug-resistant tuberculosis of the spine in a previously healthy young adult: case report.

Hanne Schreurs, Joost Dejaegher, Tom Decroo, Emmanuel André, Natalie Lorent, Liesbet Henckaerts

Abstract readCase Reports
In one paragraph

Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hanne SchreursDepartment of Internal Medicine, University Hospitals Leuven, Herestraat 49, Leuven, Leuven, 3000, Belgium. hanne.1.schreurs@uzleuven.be.
Joost DejaegherDepartment of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.
Tom DecrooUnit of HIV and TB, Institute of Tropical Medicine, Antwerp, Belgium.
Emmanuel AndréDepartment of Microbiology, University Hospitals Leuven, Leuven, Belgium.
Natalie Lorent *Department of Chronic Diseases, Metabolism and Aging, BREATHE laboratory, KU Leuven, , Leuven, Belgium.
Liesbet Henckaerts *Department of Internal Medicine, University Hospitals Leuven, Herestraat 49, Leuven, Leuven, 3000, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal tuberculosis (TB), previously known as Pott’s disease, is the most common bone infection caused by Mycobacterium tuberculosis. The diagnosis of spinal TB is based on clinical, radiographic, microbiological, and histological findings. Its indolent nature, subacute progression, paucibacillary state, and difficulties in obtaining adequate samples often result in delayed diagnosis. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB has posed significant challenges in the management of TB infections. Here, we present a case of pre-XDR tuberculosis of the spine in a 32-year-old Indian male, managed with surgical intervention, because of neurological deficits, and a second-line antituberculosis drug regimen, guided by antimicrobial susceptibility testing, including bedaquiline, linezolid, amikacin, cycloserine, and ethionamide. This case highlights the challenges associated with the diagnosis and treatment of pre-XDR spinal tuberculosis. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Antitubercular AgentsExtensively Drug-Resistant TuberculosisMycobacterium tuberculosisTuberculosis, SpinalAdultHumansLinezolidMaleMicrobial Sensitivity TestsAntitubercular AgentsLinezolidAntimicrobial susceptibility testingAntitubercular drugs and case reportMycobacterium tuberculosisPre-extensively drug-resistant spinal tuberculosis

Identifiers

PMID41484560
PMCPMC12866410

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.