Evidence map›Paper›PMID 41484548›Full record

ArticleBMC genomics2026

Genetic admixture and adaptive signatures of Guanling cattle revealed by whole-genome sequence.

Zhiyi Su, Kunyou Xian, Chenqi Bian, Fuqiang Li, Xingshan Qi, Chuzhao Lei, Xiaoting Xia

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Zhiyi SuCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Kunyou XianCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Chenqi BianCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Fuqiang LiAnimal Husbandry Bureau in Biyang County, Biyang, 463700, China.
Xingshan QiHunan Tianhua Industrial Corporation Ltd., Lianyuan, 417126, China.
Chuzhao LeiCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China. leichuzhao1118@126.com.
Xiaoting XiaCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China. xiaxiaoting1991@163.com.

Funding

China Agriculture Research System of MOF and MARA CARS-37National Key R&D Program of China 2023YFD1300100 and 2023YFD1300102National Key Research and Development Program of China 2024YFF1000102
6 · The paper itself

Abstract

backgroundGuanling cattle is a vital livestock resource in Guizhou Province, China. Characterizing their genetic diversity provides a foundation for developing effective breeding and conservation strategies. This study employed whole-genome sequencing to analyse the population genetic structure and adaptive evolution of Guanling cattle.

resultsThe results revealed that Guanling cattle are hybrids of East Asian indicine (EAI, 50%) and East Asian taurine (EAT, 35%) ancestry, exhibiting high genetic diversity and low inbreeding levels. Through local ancestry inference and selection signature analyses, several genes associated with disease resistance, heat tolerance, reproduction, and meat quality (such as STAT6, DNAJC8, HSPA4, PPP1R8, and BASP1) were identified. Notably, DNAJC8 and HSPA4, detected within selection-signal regions showing excessive EAI ancestry, were mainly related to immune and adaptive traits, whereas BASP1, identified in selection-signal regions enriched for EAT ancestry, was associated with muscle development and meat quality.

conclusionsOur findings reveal that Guanling cattle, composed of both indicine and taurine ancestries, represent a newly recognized and highly valuable genetic resource. The results provide important molecular insights for the conservation and breeding of Guanling cattle.

Indexed as

Adaptation, PhysiologicalGenomeWhole Genome SequencingAnimalsBreedingCattleGenetic VariationPolymorphism, Single NucleotideSelection, GeneticGuanling cattleHSPA4Locus-specific branch lengthSelection signaturesWhole-genome resequencing

Identifiers

PMID41484548
PMCPMC12866433

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.