Evidence map›Paper›PMID 41484507›Full record

ReviewCurrent atherosclerosis reports2026

HDL in Abdominal Aortic Aneurysm: Mechanistic Insight and Therapeutic Potential.

Julia C Catalano, Yanhong Guo, Brandon M Bordeau, Minzhi Yu, Anna Schwendeman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current atherosclerosis reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Julia C CatalanoDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Yanhong GuoDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI, USA.
Brandon M BordeauDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Minzhi YuDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA. minzhiyu@umich.edu.
Anna SchwendemanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA. annaschw@umich.edu.

Funding

Interdepartmental Training in Pharmacological SciencesT32GM140223 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lori L. Isom · 2021 to 2026
$3.8M
Development of phospholipid-based nanotherapeutics for treating abdominal aortic aneurysmR01HL165688 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yanhong Guo, Anna Schwendeman · 2023 to 2026
$3.1M
American Heart Association 24POST1196020NHLBI NIH HHS R01 HL165688NIGMS NIH HHS T32 GM140223NIH HHS GM140223NIH HHS HL165688
6 · The paper itself

Abstract

purpose of reviewThis review examines the role of high-density lipoprotein (HDL) in the context of abdominal aortic aneurysm (AAA). It focuses on the correlation between HDL and AAA risk, while also exploring the mechanisms by which HDL may protect against AAA progression. RECENT

findingsLarge epidemiological and genetic studies have consistently shown that lower HDL-cholesterol (HDL-C) levels are associated with an increased risk of AAA. HDL exerts a protective effect against AAA formation through its anti-inflammatory, antioxidant, and endothelial protective functions. Recent therapeutic strategies aimed at augmenting HDL functionality, including synthetic HDL (sHDL) and apolipoprotein A-I (ApoA-I) mimetics, have demonstrated promising results in animal models. Current evidence supports a protective role for HDL in AAA pathogenesis. Strategies aimed to improve or mimic HDL function represent promising avenues for future AAA treatment, emphasizing the need for continued translational research and clinical development.

Indexed as

Aortic Aneurysm, AbdominalCholesterol, HDLLipoproteins, HDLAnimalsApolipoprotein A-IHumansApolipoprotein A-ICholesterol, HDLLipoproteins, HDLAbdominal aortic aneurysmApolipoprotein A-1HDL therapyHigh-density lipoproteinVascular smooth muscle cells

Identifiers

PMID41484507
PMCPMC12764603

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.