Evidence map›Paper›PMID 41484499›Full record

ArticleDigestive diseases and sciences2026

Differences in Presentation and Outcomes by Type and Severity of Food Impaction Symptoms in Eosinophilic Esophagitis.

Sean S LaFata, Walker D Redd, Stefani Aleman, Alexandra A Weir, Timothy S Gee, Angelica R Lackey, Arjun K Juneja, Hannah L Thel, Brenderia A Cameron, Justin McCallen and 8 more

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Sean S LaFataCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Walker D ReddCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Stefani AlemanCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Alexandra A WeirCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Timothy S GeeCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Angelica R LackeyCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Arjun K JunejaCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Hannah L ThelCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Brenderia A CameronCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Justin McCallenCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Christopher J LeeCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Gustaf N HendrickCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Jose C BermudezCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Daniel SongCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Trevor S BarloweCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Cary C CottonCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Craig C ReedCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Evan S DellonCenter for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA. edellon@med.unc.edu.

Funding

DIGESTIVE DISEASES EPIDEMIOLOGY TRAINING PROGRAMT32DK007634 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1990 to 2026
$7.4M
SHORT-TERM RESEARCH TRAININGT35DK007386 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Evan Samuel Dellon · 1986 to 2026
$4.1M
NIDDK NIH HHS T32 DK007634NIDDK NIH HHS T35 DK007386NIH HHS T32 DK007634NIH HHS T35 DK007386
6 · The paper itself

Abstract

backgroundEsophageal food impaction (EFI) commonly occurs in eosinophilic esophagitis (EoE), but its spectrum of severity remains incompletely described.

aimsTo determine whether presentation and outcomes of EoE differ based on type of EFI.

methodsPatients with newly diagnosed EoE were categorized by EFI type: those with transient symptoms, those with an emergency department (ED) visit but no esophagogastroduodenoscopy (EGD), and those with an ED visit and EGD. Patient, EoE, and treatment data were collected. We compared characteristics and treatment responses and used multinomial logistic regression to adjust for confounders.

resultsOf 814 EFI patients with EoE, 485 had transient symptoms (symptoms-only), 76 required only an ED visit (ED-only), and 253 required an ED visit and EGD (ED + EGD). Compared to symptoms-only, ED-only and ED + EGD were more likely to have rings (67% and 70% vs 57%; p < 0.001) and stricture (41% and 44% vs 35%; p = 0.04). Topical corticosteroid (tCS) therapy led to histologic response (< 15 eos/hpf) more commonly in the symptoms-only group, followed by ED + EGD and ED-only (61% vs 52% vs 34%; p = 0.009). After tCS therapy, patients with only symptoms were less likely to have narrowing or require dilation. All EFI groups had similar responses to dietary therapy.

conclusionsIn EoE patients, most EFI symptoms self-resolved. Patients requiring at least an ED visit had more fibrostenosis at baseline, less histologic response with tCS therapy, and more persistent fibrostenosis after tCS therapy. Patients with more severe EFI presentations warrant close monitoring and endoscopic management of fibrostenotic disease.

Indexed as

Deglutition DisordersEosinophilic EsophagitisAdolescentAdrenal Cortex HormonesAdultEmergency Service, HospitalEndoscopy, Digestive SystemFemaleFoodHumansMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexTreatment OutcomeYoung AdultAdrenal Cortex HormonesDietary therapyEosinophilic esophagitisEsophageal food impactionFibrostenosisTopical corticosteroids

Identifiers

PMID41484499
PMCPMC12860973

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.