Evidence map›Paper›PMID 41484494›Full record

ReviewCurrent treatment options in oncology2026

Research Priorities and Future Directions in Cardio-Oncology.

Reed Mszar, Abdelrahman Ali, Sarah C Hull, Leah M Ferrucci, Lauren A Baldassarre, Rohan Khera, Melinda L Irwin, Suparna C Clasen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current treatment options in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Reed MszarDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, 06510, USA. reed.mszar@yale.edu.
Abdelrahman AliDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Sarah C HullSection of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, USA.
Leah M FerrucciDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, 06510, USA.
Lauren A BaldassarreSection of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, USA.
Rohan KheraSection of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, USA.
Melinda L IrwinDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, 06510, USA.
Suparna C ClasenDivision of Cardiovascular Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

opinion statementThe subspecialty of cardio-oncology has undergone significant growth in recent years, alongside major advances in the management of both cardiovascular disease and cancer, the leading causes of morbidity and mortality in the United States and many countries around the world. Contemporary clinical guidelines and scientific statements have outlined evidence-based strategies for reducing the risk of cancer therapy-related cardiovascular toxicity among cancer survivors across the treatment continuum. These approaches broadly include tailoring assessment and treatment of shared risk factors before therapy; minimizing cardiac radiation exposure, integrating baseline and repeat echocardiography for those receiving anthracyclines and targeted therapies, and assessing troponins and electrocardiography for patients starting immune checkpoint inhibitors during therapy; and considering long-term cardiac surveillance and promoting healthy lifestyle behaviors after therapy. This review outlines key evidence gaps and future directions in cardio-oncology with an emphasis on contemporary trends in cardiovascular disease and cancer risk factors, current and novel approaches for risk estimation and stratification, innovative clinical trials and largescale observational registries, quality-of-care metrics and cardio-oncology rehabilitation, social determinants of health and health equity, and artificial intelligence and machine learning for precision medicine. As the number of cancer survivors continues to grow and is projected to exceed 26 million by 2040, multidisciplinary collaboration between cardiology, oncology, and other health disciplines is critical to not only improve individuals' health outcomes and quality of life associated with cardiovascular disease and cancer, but also to further elucidate the bi-directional relationship and underlying pathophysiologic mechanisms underpinning both chronic diseases.

Indexed as

CardiologyCardiovascular DiseasesMedical OncologyNeoplasmsCardio-OncologyCardiotoxicityDisease ManagementHumansRisk FactorsCancerCardio-oncologyCardiotoxicityCardiovascular diseaseRisk factorsSurvivorship

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.