ArticleScientific reports2026
OIP5-AS1/miR-223-3p provides potential biomarkers for chronic periodontitis and its regulatory role in inflammatory responses.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chronic periodontitis (CP) is a common chronic oral infectious disease. This study evaluated the clinical significance of differentially expressed OIP5-AS1 and miR-223-3p in CP patients and investigated the biological function of the OIP5-AS1/miR-223-3p axis in a cell model induced by LPS. One hundred and eighteen CP patients were enrolled to provide clinical samples and data. OIP5-AS1 and miR-223-3p expression were detected by reverse transcription quantitative PCR, and their clinical application in diagnose CP was evaluated by receiver operative curve (ROC) analysis. Bioinformatics prediction and dual-luciferase reporter assay confirmed the interaction between OIP5-AS1 and miR-223-3p. Human periodontal ligament cells (HPLCs) were treated with LPS to establish disease cell model, and the effects of OIP5-AS1/miR-223-3p on cell viability and inflammation were examined using CCK-8 and ELISA. In CP patients, OIP5-AS1 expression was lower and miR-223-3p expression was higher than in the control group (both P < 0.001). Serum OIP5-AS1 and miR-223-3p showed considerable ability to diagnose CP from healthy controls (AUC = 0.816, sensitivity = 70.34%, specificity = 81.97% for OIP5-AS1; AUC = 0.837, sensitivity = 80.51%, specificity = 72.13% for miR-223-3p). Cell experiments showed OIP5-AS1 improved LPS-induced impaired cell proliferation by sponging miR-223-3p. Additionally, OIP5-AS1 targets miR-223-3p and inhibits the inflammatory response induced by LPS, while promoting osteogenic differentiation of HPDLCs. Serum upregulated OIP5-AS1 and downregulated miR-223-3p serve as potential diagnostic biomarkers for CP, and OIP5-AS1 might be involved in CP progression by sponging miR-223-3p.
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