Evidence map›Paper›PMID 41484174›Full record

ArticleScientific reports2026

Plasmonic imaging of living pancreatic beta-cell networks.

Sidahmed Abayzeed, Daniel Galvis, Karen Regules Medel, Catarina F Jones, Oscar Barajas Gonzalez, Kerry Setchfield, Rosalia Moreddu, Michael G Somekh, Kyle C A Wedgwood, Paul Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sidahmed AbayzeedFaculty of Engineering, University of Nottingham, Nottingham, UK. sidahmed.abayzeed2@nottingham.ac.uk.
Daniel GalvisCentre for Systems Modelling & Quantitative Biomedicine (SMQB), School of Medical Sciences, University of Birmingham, Birmingham, UK.
Karen Regules MedelFaculty of Engineering, University of Nottingham, Nottingham, UK.
Catarina F JonesSchool of Electronics and Computer Science, University of Southampton, Southampton, UK.
Oscar Barajas GonzalezFaculty of Engineering, University of Nottingham, Nottingham, UK.
Kerry SetchfieldFaculty of Engineering, University of Nottingham, Nottingham, UK.
Rosalia MoredduSchool of Electronics and Computer Science, University of Southampton, Southampton, UK.
Michael G SomekhFaculty of Engineering, University of Nottingham, Nottingham, UK.
Kyle C A WedgwoodLiving Systems Institute, University of Exeter, Exeter, UK.
Paul SmithSchool of Life Sciences, University of Nottingham, Nottingham, UK.

Funding

Engineering and Physical Sciences Research Council EP/X018024/1UK Research and Innovation MR/X034240/1
6 · The paper itself

Abstract

We present a novel plasmonic imaging technique for real-time, label-free tracking of bioelectrical interactions in live pancreatic beta-cell networks. Surface plasmon resonance microscopy (SPRM) is utilized to reveal synchronized glucose-induced intensity oscillations that are suppressed by calcium channel blockers. These oscillations are observed at the subcellular scale with a resolution of 1 μm. The technique can also uncover the extracellular spread of these oscillations beyond the cells. We further combine SPRM with network analysis to quantify coordinated electrical activity within the living cell network using both amplitude and phase-based metrics. Our results demonstrate a new method for studying electrical communication in pancreatic beta-cells, which could be crucial for understanding dysregulation in diabetes and advancing treatment development. This technique holds promise for investigating electrical connectivity in biological cell networks with applications in neuroscience, cardiac science, and bioelectricity in cancer, microbiology, development and regeneration.

Indexed as

Insulin-Secreting CellsSurface Plasmon ResonanceAnimalsGlucoseHumansMiceGlucoseBioelectrical and calcium signallingBioelectrical networksBioelectricityDiabetesLabel-free plasmonic microscopyPancreatic beta cells

Identifiers

PMID41484174
PMCPMC12855867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.