ArticleScientific reports2026
Formulation film based on zinc acetate/cellulose with anti-inflammatory, angiogenesis, and remodeling abilities for enhancing burn healing.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Biopolymer-Based Hydrogels for Wound Healing: Advances in Cellulose, Chitosan, Alginate, and Hyaluronic Acid from Design to Clinical Translation.Pharmaceuticals (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burns are most challenging to treat as they result in skin impairment or even death. This study elucidated the therapeutic benefits of Zinc/cellulose films on thermal burn injuries in rats at two distinct time points [eight and sixteen days after the injury]. A novel formulation film based on Zinc acetate and cellulose for enhancing burn healing has been prepared. Hydroxyl ethyl cellulose (HEC) and Polyvinyl alcohol have mixed to form homogenous solution then zinc acetate with different ratios has been added. The prepared film has been investigated by different analysis FTIR, XRD and SEM then applied on burn rat model using Silvazine cream as a reference drug. Our findings illustrated that treatments under investigation after 8 and 16 days enhanced wound contraction rate and improved pathological alteration triggered by burn induction. C-Zn1.5 film declined IL-1β [8 day 30.03 ± 0.24, p<0.001; 16 day 18.43 ± 0.31, p<0.001] and TNF-α [8 day 68.14 ± 0.54, p<0.001; 16 day 39.35 ± 0.55, p<0.001] levels, and increased collagen1 [8 day 3.92 ± .08, p<0.001; 16 day 6.06 ± .15, p<0.001] and Bcl2 [8 day 277.7 ± 1.26, p<0.001; 16 day 396.27 ± 2.07, p<0.001] concentrations at 8 and 16 days in burn tissues. Additionally, the C-Zn1.5 film downregulated the expression levels of VEGF (~90%), TGF-β (~91%), MMP2 (~85%), and TIMP2 (~88%) genes at day 8; however, they upregulated gene levels of VEGF (~340%), TGF-β (~313%), MMP2 (~413%), and TIMP2 (~259%) at day 16 in skin burnt tissues. Collectively, Zinc/cellulose 1.5 films was superior in promoting burn wound healing via mechanisms possibly associated with its anti-inflammatory, anti-apoptotic, angiogenesis, and remodeling abilities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.