Tunable enantioselective electrocatalytic functionalization of unactivated alkenes.

Tian Xie, Minghao Liu, Jiayin Zhang, Lingzi Peng, Chang Guo

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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Tian Xie *Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, China.

Minghao Liu *Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0009-0007-6493-9630

Jiayin ZhangHefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, China.

Lingzi PengHefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0001-5180-8040

Chang GuoHefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, China. guochang@ustc.edu.cn.ORCID http://orcid.org/0000-0003-4022-9582

Funding

National Natural Science Foundation of China (National Science Foundation of China) 21971227

6 · The paper itself

Abstract

The tunable enantioselective functionalization of alkene feedstocks represents a highly desirable yet predominantly unresolved tactic for generating high-value scaffolds. Herein, we report a tunable enantioselective electrolytic system for dehydrogenative allylation, dehydrogenative alkenylation, and hydroalkylation reactions with identical substrates to afford structurally diverse products. This success hinges on the rational design of the stereoselective coupling of an electrogenerated nickel-bound α-carbonyl radical species that can trap unactivated alkenes and engage in various subsequent radical termination processes to enable the intermolecular functionalization of unactivated alkenes. The mild reaction conditions and sustainable electrocatalytic radical platform guarantee excellent functional group tolerance and substrate compatibility with unactivated alkenes (63 examples, up to 98% e.e.), and the process evolves H₂ without the need for external chemical oxidants. The utility of this enantioselective electrolytic strategy is demonstrated by its application in the stereoselective formal synthesis of (S)-SYK inhibitor, signifying substantial progress in synthetic methods.

Identifiers

PMID41484105

DOI10.1038/s41467-025-68123-3

PMCPMC12877130

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