Evidence map›Paper›PMID 41484096›Full record

Trial reportNature communications2026

Autologous cell therapy with CD133+ bone marrow-derived stem cells for Asherman Syndrome: a phase 1/2 trial.

Xavier Santamaria, María Pardo-Figuerez, Javier González-Fernández, Sergi Querol, Luciano Rodríguez, David Valcárcel, Carla González, Estefanía Fernandez, Diego Amorós, Michael Robles and 14 more

Abstract readClinical Trial, Phase IClinical Trial, Phase II
In one paragraph

Trial report in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Xavier SantamariaCarlos Simon Foundation, Valencia, Spain. xsantamaria@fundacioncarlossimon.com.ORCID http://orcid.org/0000-0002-5689-6200
María Pardo-FiguerezCarlos Simon Foundation, Valencia, Spain.
Javier González-FernándezCarlos Simon Foundation, Valencia, Spain.ORCID http://orcid.org/0000-0002-9625-5264
Sergi QuerolDepartment of Cell Therapies, Banc de Sang i Teixits, Barcelona, Spain.
Luciano RodríguezDepartment of Cell Therapies, Banc de Sang i Teixits, Barcelona, Spain.
David ValcárcelDepartment of Hematology, Vall Hebron Institut Oncologia (VHIO), Barcelona, Spain.
Carla GonzálezDepartment of Vascular Radiology, Vall Hebron Institut de Recerca (VHIR), Barcelona, Spain.
Estefanía FernandezCarlos Simon Foundation, Valencia, Spain.
Diego AmorósCarlos Simon Foundation, Valencia, Spain.ORCID http://orcid.org/0000-0003-2035-6189
Michael RoblesCarlos Simon Foundation, Valencia, Spain.
Sofia Granados-ApariciDepartment of Pathology, Medical School, University of Valencia, Valencia, Spain.ORCID http://orcid.org/0000-0003-4448-3254
Sheila ZuñigaINCLIVA Health Research Institute, Valencia, Spain.ORCID http://orcid.org/0000-0002-3272-7605
Francisco MartinezINCLIVA Health Research Institute, Valencia, Spain.ORCID http://orcid.org/0009-0002-0760-8206
Diana ValbuenaIgenomix R&D, Valencia, Spain.ORCID http://orcid.org/0000-0002-0742-3669
Carlos GómezIgenomix R&D, Valencia, Spain.
Julio HerreroDepartment Ob/Gyn Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain.
Ramon AurellDeparment of Human Reproduction, Clínica Quirón, Barcelona, Spain.
Juan José TorrentDepartment of Obstetrics & Gynecology, Hospital Pilar, Barcelona, Spain.
Felipe VilellaCarlos Simon Foundation, Valencia, Spain.ORCID http://orcid.org/0000-0002-0039-9846
Petr VolkovCarlos Simon Foundation, Valencia, Spain.
Francisco RagaINCLIVA Health Research Institute, Valencia, Spain.
Rosa NogueraDepartment of Pathology, Medical School, University of Valencia, Valencia, Spain.ORCID http://orcid.org/0000-0003-4546-7459
Hugh S TaylorDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
Carlos SimonCarlos Simon Foundation, Valencia, Spain.ORCID http://orcid.org/0000-0003-0902-9531

Funding

Regional Government of Valencia | Conselleria d'Educació, Investigació, Cultura i Esport (Conselleria d'Educació, Investigació, Cultura i Esport de la Generalitat Valenciana) PROMETEO/2018/161
6 · The paper itself

Abstract

Autologous CD133+ bone marrow-derived stem cell (BMDSC) therapy has been designated as an Orphan Drug by the EMA and FDA for the treatment of Asherman Syndrome (AS). This phase 1/2, non-randomized, open-label, single-arm trial assessed the safety and efficacy of this novel therapy in 20 infertile women with moderate to severe AS, unresponsive to prior hysteroscopic treatments. Primary endpoints were safety and tolerability over 15 months follow-up, including during pregnancy and after live birth. The therapy was well tolerated with a mean dosage of 125.41 × 10

Indexed as

AC133 AntigenBone Marrow CellsGynatresiaStem Cell TransplantationAdultFemaleHumansPregnancyTransplantation, AutologousTreatment OutcomeYoung AdultAC133 AntigenPROM1 protein, human

Identifiers

PMID41484096
PMCPMC12852688

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.