Evidence map›Paper›PMID 41484052›Full record

ArticlePharmaceutical biology2026

Identification and characterization of five anti-mitotic sesquiterpene lactones from

Tanner C Lockwood, David E Williams, Layla Molina, Raymond J Andersen, Roy M Golsteyn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tanner C LockwoodNatural Product Laboratory, University of Lethbridge, Lethbridge, Canada.
David E WilliamsDepartment of Earth, Ocean, Atmospheric Sciences, University of British Columbia, Vancouver, Canada.
Layla MolinaNatural Product Laboratory, University of Lethbridge, Lethbridge, Canada.
Raymond J AndersenDepartment of Earth, Ocean, Atmospheric Sciences, University of British Columbia, Vancouver, Canada.
Roy M GolsteynNatural Product Laboratory, University of Lethbridge, Lethbridge, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextUnique ecozones, such as those in Canada, play an important role in the production of distinct natural product chemicals that help plants survive highly variable abiotic conditions and herbivory. Extracts prepared from

objectiveThis study aimed to identify the anti-mitotic compound(s) of MATERIALS AND

methodsThe cytotoxic and anti-mitotic activities of

resultsFive anti-mitotic sesquiterpene lactones were isolated from DISCUSSION AND

conclusionThis is the first report of mitotic inhibitors from

Indexed as

Antimitotic AgentsAntineoplastic Agents, PhytogenicArnicaLactonesMitosisPlant ExtractsSesquiterpenesCell Line, TumorDose-Response Relationship, DrugHeLa CellsHumansAntimitotic AgentsAntineoplastic Agents, PhytogenicLactonesPlant ExtractsSesquiterpenesAnti-mitoticArnica cordifoliaAsteraceaeMitotic spindleSesquiterpene lactones

Identifiers

PMID41484052
PMCPMC12777910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.