Evidence map›Paper›PMID 41483811›Full record

ArticleStem cell reports2026

Atypical cell cycle regulation over neural stem cell expansion.

Dorota Lubanska, Ingrid Qemo, Keith Franklin Stringer, Hema Priya Mahendran, Bre-Anne Fifield, Alan Cieslukowski, Sami Alrashed, Youshaa El-Abed, Emmanuel Boujeke, Alexander Rodzinka and 9 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Dorota LubanskaUniversity of Windsor, Windsor, ON, Canada.
Ingrid QemoUniversity of Windsor, Windsor, ON, Canada.
Keith Franklin StringerUniversity of Windsor, Windsor, ON, Canada.
Hema Priya MahendranUniversity of Windsor, Windsor, ON, Canada.
Bre-Anne FifieldUniversity of Windsor, Windsor, ON, Canada.
Alan CieslukowskiUniversity of Windsor, Windsor, ON, Canada.
Sami AlrashedUniversity of Windsor, Windsor, ON, Canada; University of Ottawa, Faculty of Medicine, Ottawa, ON, Canada.
Youshaa El-AbedUniversity of Windsor, Windsor, ON, Canada; The University of Kansas School of Medicine, Kansas City, KS, USA.
Emmanuel BoujekeUniversity of Windsor, Windsor, ON, Canada; Western University, Schulich School of Medicine & Dentistry, London, ON, Canada.
Alexander RodzinkaUniversity of Windsor, Windsor, ON, Canada; University of Toronto, Temerty Faculty of Medicine, Toronto, ON, Canada.
Elizabeth Fidalgo da SilvaUniversity of Windsor, Windsor, ON, Canada.
Stephanie DinescuUniversity of Windsor, Windsor, ON, Canada.
Alexandra SorgeUniversity of Windsor, Windsor, ON, Canada.
Srinath KandalamUniversity of Windsor, Windsor, ON, Canada; MediCiti Institute of Medical Sciences, Ghanpur, India.
Dalton LiwanpoUniversity of Windsor, Windsor, ON, Canada.
Jillian BrownUniversity of Windsor, Windsor, ON, Canada; University of Duisburg-Essen, Essen, Germany.
Hasan GhafoorUniversity of Windsor, Windsor, ON, Canada.
Maheen ArshadUniversity of Windsor, Windsor, ON, Canada.
Lisa A PorterUniversity of Windsor, Windsor, ON, Canada; WE-SPARK Health Institute, Windsor, ON, Canada. Electronic address: lporter@uwindsor.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Populations of adult neural stem cells (NSCs) that reside in the mammalian brain aid in neurogenesis throughout life and can be identified by a type VI intermediate filament protein, Nestin. Cell cycle regulation plays an important role in maintaining a balance between self-renewal and differentiation and determining the fate of NSCs. Data from our group and others support that the atypical cyclin-like protein SPY1 (also called RingoA; gene SPDYA) plays a critical role in activating NSCs from a quiescent state. Elevated levels of Spy1 are found in aggressive human brain cancers, including glioblastoma. Using a conditional mouse model, we demonstrate that driving the expression of Spy1, in the Nestin-enriched NSC population of the brain, increases stemness characteristics, decreases differentiation, and increases susceptibility to oncogenic transformation. This study contributes to better understanding of intricate cell cycle mechanisms that lead to deviation from the homeostatic state, promoting aberrant changes in adult NSCs.

Indexed as

Cell CycleCell Cycle ProteinsNeural Stem CellsAnimalsCell DifferentiationCell ProliferationHumansMiceNestinNeurogenesisCell Cycle ProteinsNestinbrain developmentbrain tumourscell cycledifferentiationNestinneural stem cellsoncogenesisRINGOSPDYAtransgenic mouse models

Identifiers

PMID41483811
PMCPMC12925950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.