ReviewStem cell reports2026
Hematopoietic organoids: Opportunities and challenges in modeling human hematopoiesis and diseases in vitro.
Review in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Previous studies on hematopoiesis were mainly conducted in model animals. However, direct investigation of human hematopoiesis remains challenging due to limited access to human samples and ethical concerns. Traditional two-dimensional culture systems have provided valuable opportunities to study human hematopoiesis, but they fail to fully recapitulate the behaviors of hematopoietic cells and their interactions with niche cells as observed in vivo. In recent years, organoid technologies have emerged as a powerful approach for modeling hematopoietic development, maintenance, and diseases. By mimicking the key architectural and functional characteristics of native hematopoietic tissues, hematopoietic organoids (HOs) offer promising platforms for studying developmental hematopoiesis, modeling hematological diseases, performing drug screening, and generating functional hematopoietic cells. In this review, we summarize recent progress in HO construction, explore their potential applications in both basic research and clinical translation, and discuss current opportunities and remaining challenges in generating physiologically relevant HO models.
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