Evidence map›Paper›PMID 41483805›Full record

ArticleCell reports. Medicine2026

Targeting senescent EGR1

Pingjing Zhou, Yuchen Zhang, Hongyu Zhang, Pengyuan Zhao, Yifan Guo, Guangyin Zhao, Yiwei Chu, Di Ge, Ronghua Liu, Jie Gu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pingjing ZhouDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yuchen ZhangDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Hongyu ZhangDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Pengyuan ZhaoFifth People's Hospital and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Yifan GuoDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Guangyin ZhaoDepartment of Thoracic Surgery, Shanghai Geriatric Medical Center, Zhongshan Hospital, Fudan University, Minhang Meilong, Shanghai 201100, China.
Yiwei ChuDepartment of Immunology, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Di GeDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: ge.di@zs-hospital.sh.cn.
Ronghua LiuFifth People's Hospital and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China. Electronic address: ronghualiu@fudan.edu.cn.
Jie GuDepartment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: gu.jie3@zs-hospital.sh.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms for failure of neoadjuvant immune checkpoint blockade (NICB), an established therapy for patients with esophageal squamous cell carcinoma (ESCC), remain unclear. We integrated single-cell RNA data from patients with ESCC pre- and post-NICB, identifying a subset of senescent EGR1-expressing B cells that correlate with poor pathological responses. EGR1 was a key transcription factor regulating B cell senescence. EGR1

Indexed as

B-LymphocytesCellular SenescenceEarly Growth Response Protein 1Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaImmunotherapyAnimalsFemaleFlavonoidsHumansImmune Checkpoint InhibitorsMiceSenescence-Associated Secretory PhenotypeTumor-Associated MacrophagesTumor MicroenvironmentEarly Growth Response Protein 1EGR1 protein, humanFlavonoidsImmune Checkpoint Inhibitorscellular senescenceEGR1esophageal squamous cell carcinomaimmune checkpoint blockadesenescence-associated secretory phenotypesingle-cell RNA sequencingTREM2(+) tumor-associated macrophagestumor-infiltrating B cells

Identifiers

PMID41483805
PMCPMC12866087

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.