ArticleNuclear medicine and biology
PET evaluation of cholinergic system differences in progressive supranuclear palsy and age-matched controls using [
Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe availability of binding sites for the vesicular acetylcholine transporter (VAChT) provides a measure of presynaptic cholinergic neuron terminals, which undergo degeneration in various conditions, including progressive supranuclear palsy (PSP). We used a VAChT-specific PET radiotracer, [
resultsSignificant reduction of >9 % in DVR and SUVR values was observed in PSP in the entorhinal cortex (FDR-corrected p ≤ 0.023), while significant reduction of >10 % in the DVR values only was observed in the caudate (FDR-corrected p = 0.044). Exploratory analyses suggested that PSP patients had lower DVR and SUVR values in thalamus, hippocampus, caudal anterior cingulate, isthmus cingulate, lateral occipital cortex, lingual, pars orbitalis, pericalcarine, posterior cingulate, superior temporal, supramarginal, and transverse temporal regions compared to HCs. Exploratory analyses also revealed that DVR and SUVR of the brainstem correlated with disease duration (|ρ| > 0.877, p ≤ 0.003), whereas DVR and SUVR of the ventral diencephalon and brainstem correlated with MoCA scores (|ρ| > 0.48, p ≤ 0.008). No region correlated with UPDRS-III. SUVR (100-120 min) correlated well with DVR. PVC did not improve correlations with clinical measures.
conclusionsLower [
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