ArticleEuropean geriatric medicine2026
Longitudinal study on the relationship between extracellular water distribution changes and muscle mass in severe sarcopenia patients using multi-frequency bioelectrical impedance analysis combined with phase angle measurements.
Article in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to explore whether changes in extracellular water distribution and phase angle can serve as early markers of muscle loss in patients with severe sarcopenia.
methodsA 12-month prospective study enrolled 128 severe sarcopenia patients (72 M, 56F; mean age 74.3 ± 6.8y), with regular multi-frequency bioelectrical impedance analysis (5-500 kHz) and phase angle measurement at 50 kHz. Body composition, physical function, and inflammation markers were periodically assessed.
resultsOf the 128 enrolled participants, 112 (87.5%) completed the study. Muscle mass decreased significantly over 12 months, with the most rapid loss occurring between months 3-6. Phase angle also declined consistently, and a drop of ≥ 0.3° over three months effectively predicted accelerated muscle loss. Changes in bioimpedance parameters appeared nearly three weeks before detectable muscle loss. The extracellular water-to-total body water ratio rose progressively and correlated strongly with muscle mass reduction. Limb regions showed more notable deterioration than the trunk.
conclusionMulti-frequency bioelectrical impedance analysis combined with phase angle measurement offers a non-invasive and sensitive approach for early detection of muscle mass loss in severe sarcopenia. Shifts in electrical parameters and water distribution precede measurable muscle decline, highlighting a potential window for timely intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.