Evidence map›Paper›PMID 41483238›Full record

ArticleArchives of gynecology and obstetrics2026

Synergistic use of 1,5-AG and HbA1c for early prediction of gestational diabetes: capturing BMI-dependent glycemic phenotypes.

Sho Tano, Tatsuo Inamura, Kazuya Fuma, Seiko Matsuo, Kenji Imai, Satoru Katsuki, Yasuyuki Kishigami, Hidenori Oguchi, Tomomi Kotani, Takafumi Ushida and 1 more

Abstract readMulticenter Study
In one paragraph

Article in Archives of gynecology and obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sho TanoDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-Ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan. tano.sho.v4@f.mail.nagoya-u.ac.jp.
Tatsuo InamuraDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-Ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan.
Kazuya FumaDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-Ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan.
Seiko MatsuoDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-Ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan.
Kenji ImaiDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-Ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan.
Satoru KatsukiDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-Ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan.
Yasuyuki KishigamiDepartment of Obstetrics, Perinatal Medical Center, Toyota Memorial Hospital, Toyota, Aichi, 471-8513, Japan.
Hidenori OguchiDepartment of Obstetrics, Perinatal Medical Center, Toyota Memorial Hospital, Toyota, Aichi, 471-8513, Japan.
Tomomi KotaniDepartment of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, 431-3192, Japan.
Takafumi UshidaDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-Ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan.
Hiroaki KajiyamaDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-Ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan.

Funding

Japan Society for the Promotion of Science 23K19800
6 · The paper itself

Abstract

purposeRecognizing metabolic heterogeneity in gestational diabetes mellitus (GDM) and body mass index (BMI)-linked phenotypes, we evaluated whether combining hemoglobin A1c (HbA1c, reflecting fasting glycaemia) and 1,5-anhydroglucitol (1,5-AG, reflecting post-load glucose excursions) improves early prediction and whether performance differs by BMI.

methodsIn this multicenter retrospective study, pregnant women who had 1,5-AG and HbA1c measured before 20 weeks of gestation at two tertiary centers in Japan were included. Spearman's correlation was used to assess associations between glycemic markers and glucose levels. Predictive performance for GDM was evaluated using ROC analysis, and stratified analyses were conducted by pre-pregnancy BMI.

resultsAmong 191 participants, 45 (24.1%) developed GDM: 35.1 ± 4.9 years, pre-pregnancy BMI 22.9 ± 4.3 kg/m

conclusionCombining 1,5-AG and HbA1c enhances early prediction of GDM by capturing complementary glycemic abnormalities linked to BMI-specific metabolic phenotypes.

Indexed as

Blood GlucoseBody Mass IndexDeoxyglucoseDiabetes, GestationalGlycated HemoglobinAdultBiomarkersFemaleHumansPhenotypePredictive Value of TestsPregnancyRetrospective StudiesROC Curve1,5-anhydroglucitolBiomarkersBlood GlucoseDeoxyglucoseGlycated Hemoglobinhemoglobin A1c protein, human1,5-AnhydroglucitolGlycemic variabilityPostprandial hyperglycemiaPredictive modelPre-pregnancy BMI

Identifiers

PMID41483238
PMCPMC12764630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.