ReviewDie Ophthalmologie2026
[New tissue-additive procedures to improve vision in keratoconus].
Review in Die Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
backgroundKeratoconus is a progressive corneal disease that can lead to substantial impairment of vision. While conventional treatment, such as glasses, contact lenses or corneal grafting are well established, minimally invasive tissue-additive procedures are becoming increasingly more important. The goal is to achieve biomechanical stabilization and optical reconstruction of the cornea with minimal invasiveness.
objectiveThis review explores what role novel tissue-additive procedures, such as stromal lenticule addition keratoplasty (SLAK), Bowman membrane transplantation and xenotransplantation, play in modern keratoconus treatment and how effective they are in terms of vision improvement and corneal stabilization. MATERIAL AND
methodsReview paper presenting the physiological principles, technical implementation and clinical results of various tissue-additive procedures. Case series, clinical studies and meta-analyses on efficacy and safety were included.
resultsTissue additive procedures, such as SLAK showed significant improvements in visual acuity and corneal topography. The central corneal thickness also increased. Combinations with corneal crosslinking (CXL) enable an expanded range of applications. Bowman's membrane transplantation also showed structural improvements in advanced keratoconus. Xenogeneic transplants from porcine stroma are promising but require further evaluation.
conclusionTissue additive techniques offer customizable, reversible alternatives to traditional transplantations with shorter recovery times. The combination with CXL improves long-term stability. Limitations include tissue availability and standardization of procedures. In the future, artificial intelligence (AI)-supported planning and image-guided treatment customization could further improve precision and outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.