Evidence map›Paper›PMID 41483149›Full record

ArticleNeuroscience bulletin2026

Hierarchical Channel System Drives Stimulus Specificity and Polymodal Encoding in A Mechano-Cold Sensory Neuron.

Linhui Zhu, Huitaong Hong, Mengyi Qian, Wang Cao, Zirui Luo, Jianke Gong, Wenjuan Zou, Lijun Kang

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Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Linhui Zhu *College of Life Science and Technology, Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology, Wuhan, 430074, China.
Huitaong Hong *Department of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, 322000, China.
Mengyi Qian *Department of Neurosurgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Wang CaoDepartment of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, 322000, China.
Zirui LuoDepartment of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, 322000, China.
Jianke GongCollege of Life Science and Technology, Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology, Wuhan, 430074, China.
Wenjuan ZouDepartment of Neurosurgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Lijun KangDepartment of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, 322000, China. kanglijun@zju.edu.cn.ORCID http://orcid.org/0000-0001-9939-5134

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymodal sensory neurons integrate diverse stimuli for environmental perception, but their modality discrimination mechanisms remain unclear. We focused on Caenorhabditis elegans inner labial type 1 (IL1) neurons, key polymodal neurons mediating mechanical and cold responses, and identified a hierarchical channel system supporting their multimodal function. Specifically, DEG-1 sodium channels are dedicated mechanotransduction receptors; GLR-3 glutamate receptors are the main rapid cold sensors, driving cold-induced calcium signals and behaviors; TRPA-1 bidirectionally modulates mechanical adaptation via calcium signaling and promotes cold-related longevity. This framework reveals a polymodal design logic: dedicated channels (DEG-1/GLR-3) process discrete modalities in parallel for specificity, while TRPA-1 regulates both. Our work provides a molecular blueprint for IL1's precise stimulus processing, offering insights into conserved multimodal integration mechanisms across lineages.

Indexed as

Caenorhabditis elegans ProteinsMechanoreceptorsMechanotransduction, CellularSensory Receptor CellsThermosensingAnimalsCaenorhabditis elegansCalcium SignalingCold TemperatureMembrane ProteinsCaenorhabditis elegans ProteinsDeg-1 protein, C elegansMembrane ProteinsCold receptorMechano-gated channelMechanosensationPolymodal sensationThermosensationTRP channel

Identifiers

PMID41483149
PMCPMC13424036

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.