Evidence map›Paper›PMID 41483147›Full record

ArticleNeuroscience bulletin2026

N-myristoyl Transferase Maintains Type II Neuroblasts through Notch Signaling in Drosophila.

Sifan Gong, Shuliu Zhang, Xu Yan, Wenting Gong, Qingxia Zhou, Xiaojing Yang, Kun Yang, Menglong Rui, Su Wang

Abstract read
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Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sifan Gong *School of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Southeast University, Nanjing, 210096, China.ORCID http://orcid.org/0009-0003-2846-4659
Shuliu Zhang *School of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Southeast University, Nanjing, 210096, China.ORCID http://orcid.org/0009-0009-5048-4692
Xu YanSchool of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Southeast University, Nanjing, 210096, China.
Wenting GongSchool of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Southeast University, Nanjing, 210096, China.ORCID http://orcid.org/0009-0008-4819-1527
Qingxia ZhouSchool of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Southeast University, Nanjing, 210096, China.ORCID http://orcid.org/0009-0006-6559-4497
Xiaojing YangSchool of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Southeast University, Nanjing, 210096, China.ORCID http://orcid.org/0000-0003-0464-712X
Kun YangDepartment of Neurosurgery, Zhongda Hospital, Southeast University, Nanjing, 210096, China. yungkun@126.com.ORCID http://orcid.org/0000-0002-0273-2198
Menglong RuiSchool of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Southeast University, Nanjing, 210096, China. ruimenglong@seu.edu.cn.ORCID http://orcid.org/0000-0002-1911-8397
Su WangSchool of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Southeast University, Nanjing, 210096, China. wangsu@seu.edu.cn.ORCID http://orcid.org/0000-0002-3167-6420

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of a complex nervous system relies on precisely regulated heterogeneity and population stability among multiple types of neural stem cells (NSCs). In Drosophila melanogaster, the larval NSCs consist of type I neuroblasts (I NBs) and type II neuroblasts (II NBs). While the division pattern of II NB lineages is similar to the cortical expansion of primates, the detailed mechanism governing their maintenance is still not completely understood. Here, we demonstrate that the N-myristoyl transferase (NMT) in Drosophila serves as a critical regulator to maintain II NBs identity through N-myristoylation. Mechanistically, NMT myristoylates the proteasome subunit P26s4 that negatively regulates Hairless, an antagonist of Notch, consequently sustaining normal Notch activity. In human brain organoids, the function of NMT is conserved in the maintenance and proliferation of NSCs. Overall, this research not only reveals significant roles of NMT and N-myristoylation in II NB maintenance but also highlights a novel mechanism of how post-translational modification (PTM) regulates the homeostasis among heterogeneous NSCs during neurogenesis.

Indexed as

AcyltransferasesDrosophila ProteinsNeural Stem CellsNeurogenesisReceptors, NotchSignal TransductionAnimalsBrainCell ProliferationDrosophila melanogasterHumansAcyltransferasesDrosophila Proteinsglycylpeptide N-tetradecanoyltransferaseN protein, DrosophilaReceptors, NotchDrosophila melanogasterN-myristoylationNotch signalingType II neuroblasts (II NBs)

Identifiers

PMID41483147
PMCPMC13388628

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.