Evidence map›Paper›PMID 41483057›Full record

ArticleMikrochimica acta2026

Silver nanocubes-based plasmon-enhanced fluorescence for amplified detection and in situ tracking of amyloid-β aggregate.

Chenye Xu, Rong Xu, Xiangyuan Yin, Yaqiong Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chenye XuKey Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, P. R., China.
Rong XuKey Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, P. R., China.
Xiangyuan YinKey Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, P. R., China.
Yaqiong YangKey Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, P. R., China. yangyq@njnu.edu.cn.

Funding

Jiangsu Basic Research Center for Synthetic Biology BK20233003National Natural Science Foundation of China 21904064
6 · The paper itself

Abstract

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by the pathological aggregation of amyloid-β (Aβ) protein. In this study, a plasmon-enhanced fluorescence (PEF) sensor based on Ag nanocubes (Agcubes) was developed for in situ imaging and tracking of Aβ1−42 (Aβ42) aggregation states. By precisely tuning the thickness of the silicon shell of the PEF sensor, the distance between rose bengals (RB) and Agcubes was optimized, leading to a remarkable 7.4-fold enhancement in fluorescence signal compared to RB. This sensor exhibited a significant “turn-on” response towards Aβ42 aggregation, with an approximate 4.5-fold increase in fluorescence. Notably, the sensor could be successfully applied to detect and locate the process of Aβ42 aggregation in living human neuroblastoma (SH-SY5Y) cells. Additionally, its staining sites were nearly identical to those of the commercial dye thioflavin T (ThT). This method enabled real-time in situ monitoring of intracellular Aβ42 aggregation state, demonstrating great potential as a reliable diagnostic tool for AD.

Indexed as

Amyloid beta-PeptidesMetal NanoparticlesPeptide FragmentsSilverFluorescent DyesHumansProtein AggregatesSurface Plasmon ResonanceAmyloid beta-PeptidesFluorescent DyesPeptide FragmentsProtein AggregatesSilverAg nanocubesAlzheimer’s diseaseAmyloid-β aggregatesPlasmon-enhanced fluorescenceRose bengals

Identifiers

PMID41483057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.