ArticleResearch on child and adolescent psychopathology2026
Development of Substance Use Problems: The Role of Adolescent Cannabis Age of Onset, Frequency of Use and Childhood Risk Factors.
Article in Research on child and adolescent psychopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- How adolescent cannabis use reshapes the developing brain - a systematic review.Frontiers in psychiatry · 2026Pooled it
- Longitudinal Bidirectional Associations Between Early Adolescents' Externalizing and Posttraumatic Stress Symptoms and Substance Use Patterns.Research on child and adolescent psychopathology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Substance use (SU) problems are critical public health concerns. This study investigated how childhood risk factors and cannabis age of onset (CAO) in adolescence predict later SU problems, using data from the two cohorts of the Quebec Longitudinal Study of Child Development (N = 306; 57% female; N = 1489; 54% female), followed from birth to age 23. A direct association between early CAO and increased cannabis use problems was found in males (cohort 1: β = -0.47; cohort 2: β = -0.22), but not in females. In both sexes, CAO was indirectly associated with later cannabis use problems via increased adolescent cannabis use frequency (cohort 1: ab = -0.41; cohort 2: ab = -0.35). Similar indirect associations were observed between CAO and other SU problems (including tobacco and alcohol), via adolescent cannabis use frequency (cohort 1: ab = -2.63). Parental cannabis use, adverse childhood experiences, and childhood externalizing behaviors (i.e., physical aggression and ADHD symptoms) were associated with early CAO and subsequent CU problems. These findings support developmental models linking early risk exposures to maladaptive substance use pathways and underscore the importance of prevention strategies targeting early cannabis initiation and modifiable early-life risk factors to reduce long-term SU-related problems.
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41483051What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.