ArticleCurrent microbiology2026
Extraction, Partial Characterization and Evaluation of the Biopotential of Melanin Pigment from an Indigenous non-conventional Fungus.
Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Fungal melanin as a bioactive biopolymer: structural diversity, oxidative stress modulation, anticancer mechanisms, and therapeutic perspectives.RSC advances · 2026Review
- Optimized melanin production from marine-associated Bacillus sp. EGY7 as a sustainable precursor of carbon dots for biomedical applications.Bioresources and bioprocessing · 2026Article
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2 authors.
Funding
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Abstract
Melanins are complex pigments generated when fungi, animals, plants, and bacteria oxidatively polymerize phenolic/indolic chemicals. Throughout history, this ubiquitous pigment has been utilized in various industrial applications attributed to its many qualities and uses across numerous sectors. This study focuses on the extraction and characterization of the melanin pigment of the rare Indian fungus Trichomerium bhatii NFCCI 4305. Potato dextrose broth was used for submerged fermentation of the pure fungal culture, and further, the black pigment was recovered from the biomass via alkali-acid treatment and then, purified. Through the use of UV spectroscopy, FTIR analysis, thermogravimetric analysis, and several physicochemical studies, the black pigment obtained was identified as "melanin". Elemental analysis suggests that the pigment may actually be eumelanin. The purified melanin exhibited significant biological activities. Antimicrobial assays showed MIC values of 62.5 µg/mL for Raoultella planticola, 125 µg/mL for Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicansi and 250 µg/mL for Pseudomonas aeruginosa MTCC 2453. Antioxidant activity assessed using the DPPH radical-scavenging assay demonstrated a dose-dependent response (20-100 µg/mL) with an IC₅₀ of 4.35 µg/mL. Cytotoxicity analysis revealed only a mild, dose-dependent decrease in cell viability (56% to 40% across 5-320 µg/mL), indicating good biocompatibility. T. bhatii NFCCI 4305 melanin's encouraging biological activity points to possible industrial uses for it. This is the first study that we are aware of those reports and describes melanin pigment from the Trichomerium genus.
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