ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Deciphering autoimmune encephalitis: Immune mechanisms, therapeutic paradigms, and global research trends.
Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundAutoimmune encephalitis (AE) comprises a heterogeneous group of neurological disorders characterized by autoantibodies targeting neuronal cell surface or synaptic proteins, leading to severe central nervous system dysfunction. Recent advancements in understanding AE’s pathogenic mechanisms and therapeutic strategies have been significant; yet, a comprehensive bibliometric analysis of global research trends in AE pathogenesis and therapeutic interactions remains lacking.
methodsPublications on AE pathogenesis and treatment from 1996 to 2024 were retrieved from the Web of Science (WoS) database. Bibliometric tools including VOSviewer and CiteSpace were employed to analyze publication outputs, citation networks, key research themes, and trends.
resultsThe analysis identified 2,728 articles involving 12,426 researchers from 3,153 institutions across 98 countries, showing increased publication growth particularly after 2017. The United States dominated in publication output, with the University of Pennsylvania ranking highest in total citations. Predominant research topics were AE pathogenesis, autoantibody characterization, and immunotherapeutic approaches. Keywords clustering highlighted core areas: neuronal receptor mechanisms, autoantibody subtypes, interplay with infections and autoimmune conditions, age-specific clinical presentations, and diagnostic approaches.
conclusionThis bibliometric study underscores the evolving and intricate relationship between AE’s pathogenesis and therapeutic strategies. Future research should prioritize elucidating precise immune mechanisms underlying AE to facilitate targeted and individualized treatments, ultimately enhancing clinical management and patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.