Evidence map›Paper›PMID 41482983›Full record

ArticleEuropean journal of pain (London, England)2026

Reduced Descending Itch Inhibition in Peripheral Neuropathy Patients With Chronic Pruritus.

Jonas Eck, Stephan Bigalke, Martin Schmelz, Daniela Constanze Rosenberger, Bruno Pradier, Frank Rutsch, Claudia Sommer, Frank Birklein, Daniel Segelcke, Esther Pogatzki-Zahn

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Article in European journal of pain (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonas EckDepartment of Anaesthesiology Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Stephan BigalkeDepartment of Anaesthesiology Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Martin SchmelzDepartment of Experimental Pain Research, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Daniela Constanze RosenbergerDepartment of Anaesthesiology Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Bruno PradierDepartment of Anaesthesiology Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Frank RutschDepartment of General Pediatrics, Muenster University Children's Hospital, Münster, Germany.
Claudia SommerDepartment of Neurology, University Hospital Würzburg, Würzburg, Germany.
Frank BirkleinDepartment of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Daniel SegelckeDepartment of Anaesthesiology Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.ORCID https://orcid.org/0000-0002-4405-2596
Esther Pogatzki-ZahnDepartment of Anaesthesiology Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.ORCID https://orcid.org/0000-0003-0981-3940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeripheral neuropathies (PNP) cause a wide range of symptoms of which pruritus and pain are a major burden to patients. Clarifying their mechanisms will facilitate the adequate symptom management. In contrast to neuropathic pain, neuropathic pruritus has long been understudied. We investigate inhibitory pruritus mechanisms in patients with PNP.

methodsA total of 39 participants (median age: 57 years [27-81], 25♀/14♂), including 16 patients with PNP and pruritus (PNP

resultsUsing our novel CIM protocol, well-controlled and stable itch was electrically induced in controls and in both PNP groups, regardless of whether or not pruritus was a symptom. Concomitant painful cold stimuli reduced electrically induced itch in all three groups to a similar degree. However, PNP

conclusionsThe results show reduced endogenous itch inhibition in patients with chronic itch, which represents a possible mechanism of chronic pruritus in PNP. SIGNIFICANCE STATEMENT: Reduced itch inhibition is associated with the symptom of chronic pruritus in PNP patients, suggesting that reduced descending itch inhibition may facilitate chronic itch in peripheral neuropathy.

Indexed as

Peripheral Nervous System DiseasesPruritusAdultAgedAged, 80 and overChronic DiseaseFemaleHumansMaleMiddle AgedNeuralgia

Identifiers

PMID41482983
PMCPMC12764315

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.