Evidence map›Paper›PMID 41482969›Full record

ArticleACS applied bio materials2026

Microalgae-Derived Extracellular Vesicle-Loaded 3D Alginate Hydrogels Promote In Vitro Skin and Bone Repair through Dual Fibroblast and Mesenchymal Stem Cell Modulation.

Noemi De Cesare, Luna Ardondi, Tommaso Pusceddu, Lucia Sileo, Maria Pia Cavaleri, Ilaria Vitali, Francesco Grassi, Brunella Grigolo, Giuseppe Pezzotti, Ugo D'Amora and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Noemi De CesareInstitute of Polymers, Composites and Biomaterials─National Research Council (IPCB-CNR), Naples 80125, Italy.
Luna ArdondiDepartment of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.
Tommaso PuscedduDepartment of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.
Lucia SileoDepartment of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.
Maria Pia CavaleriDepartment of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.
Ilaria VitaliDepartment of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.
Francesco GrassiLaboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, Bologna 40136, Italy.ORCID 0000-0002-5127-9561
Brunella GrigoloLaboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, Bologna 40136, Italy.
Giuseppe PezzottiBiomedical Engineering Center, Kansai Medical University, 1-9-11 Shin-machi, Hirakata, Osaka 573-1191, Japan.
Ugo D'AmoraInstitute of Polymers, Composites and Biomaterials─National Research Council (IPCB-CNR), Naples 80125, Italy.ORCID 0000-0002-6142-059X
Letizia FerroniMaria Cecilia Hospital, GVM Care and Research, Cotignola 48033, Italy.
Alfredo RoncaInstitute of Polymers, Composites and Biomaterials─National Research Council (IPCB-CNR), Naples 80125, Italy.
Barbara ZavanDepartment of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.ORCID 0000-0002-4779-4456

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic skin wounds with underlying bone exposure represent a major clinical challenge, characterized by impaired healing and limited tissue regeneration. Sustainable, biologically active biomaterials capable of addressing both cutaneous and bone repair remain highly desirable. Here, we developed three-dimensional (3D) printed sodium alginate (SA) and alginate/hydroxyapatite (SA/HAP) hydrogels incorporating microalgae-derived extracellular vesicles (MdEVs) obtained from

Indexed as

AlginatesBiocompatible MaterialsExtracellular VesiclesHydrogelsMesenchymal Stem CellsMicroalgaeCells, CulturedCell SurvivalFibroblastsHumansMaterials TestingParticle SizePrinting, Three-DimensionalSkinTissue ScaffoldsWound HealingAlginatesBiocompatible MaterialsHydrogels3D printed hydrogeldiabetic ulcer carehydroxyapatitemicroalgae-derived extracellular vesiclessodium alginate

Identifiers

PMID41482969
PMCPMC12820966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.