Evidence map›Paper›PMID 41482875›Full record

ArticleMolecular pain

Electroacupuncture at Zusanli (ST36) alleviates paclitaxel-induced neuropathic pain in rats via regulating TLR4 signaling pathway in the spinal cord.

Man-Ni Wang, Yuan-Xi Zhou, Yu-Xue Zhao, Jing-Wei Tan, Xiao Sang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Man-Ni WangInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.ORCID 0009-0003-3585-177X
Yuan-Xi ZhouInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Yu-Xue ZhaoInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.ORCID 0000-0003-0512-3408
Jing-Wei TanInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Xiao SangInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paclitaxel (PTX) treatment induces a pathological pain state that is often associated with neuroinflammation in the central nervous system. The available interventions for PTX-induced pathological pain encounter adverse effects and limited efficacies. Recent studies have shown the significant effectiveness of Electroacupuncture (EA) in pain management as a simple and safe alternative medical treatment. Here, we evaluated the analgesic effect of EA on pain behaviors in PTX-treated rats and investigated its potential analgesic mechanisms. In this study, a pathological pain model was established in SD rats via intraperitoneal (

Indexed as

Acupuncture PointsElectroacupunctureNeuralgiaPaclitaxelSignal TransductionSpinal CordToll-Like Receptor 4AnimalsAstrocytesCytokinesHyperalgesiaMaleMicrogliaNeuronsRatsRats, Sprague-DawleyCytokinesPaclitaxelTlr4 protein, ratToll-Like Receptor 4electroacupunctureneuroglianeuronsPaclitaxel-induced pathologic painToll-like receptor 4

Identifiers

PMID41482875
PMCPMC12883719

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.