Evidence map›Paper›PMID 41482857›Full record

ArticleAnnals of neurology2026

Profiles and Predictors of Neurodevelopmental Outcome at 5-6 Years in Children With a History of Acute Provoked Neonatal Seizures.

Hannah C Glass, Adam L Numis, Janet S Soul, Courtney J Wusthoff, Monica E Lemmon, Giulia M Benedetti, Catherine J Chu, Shavonne L Massey, Cameron Thomas, Tayyba Anwar and 10 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hannah C GlassDepartment of Neurology and Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-3879-1966
Adam L NumisDepartment of Neurology and Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1594-9812
Janet S SoulDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6998-7753
Courtney J WusthoffDepartment of Neurology, University of California Davis Health, Sacramento, CA, USA.
Monica E LemmonDepartment of Pediatrics and Population Health Sciences, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-6253-775X
Giulia M BenedettiDepartment of Pediatrics, C. S. Mott Children's Hospital and the University of Michigan, Ann Arbor, MI, USA.
Catherine J ChuDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Shavonne L MasseyDepartment of Neurology and Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Philadelphia, PA, USA.
Cameron ThomasDepartment of Pediatrics, University of Cincinnati College of Medicine Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Tayyba AnwarDepartment of Neurology and Pediatrics, Children's National Hospital and The George Washington University School of Medicine, Washington, DC, USA.ORCID 0000-0002-1686-8352
Julie SturzaDepartment of Pediatrics, C. S. Mott Children's Hospital and the University of Michigan, Ann Arbor, MI, USA.
Madison M BerlDepartment of Psychiatry and Behavioral Sciences, Children's Research Institute, Children's National Hospital, George Washington University, Washington, DC, USA.ORCID 0000-0002-2469-1518
Yi LiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Elizabeth E RogersDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA, USA.
Stephanie RauDepartment of Physical Medicine and Rehabilitation, Division of Rehabilitation Psychology Neuropsychology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-4786-0131
Jennifer C Gidley LarsonDepartment of Physical Medicine and Rehabilitation, Division of Rehabilitation Psychology Neuropsychology, University of Michigan, Ann Arbor, MI, USA.
Jennifer L GuerreroNeonatal Seizure Registry Parent Advisory Panel Member, Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.
Linda S FranckDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA, USA.
Charles E McCullochDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1279-6179
Renée A ShellhaasDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.

Funding

Neonatal Seizure Registry Developmental Functional EValuation (NSR-DEV)R01NS111166 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLASS, HANNAH CRANLEY, SHELLHAAS, RENEE A. · 2020 to 2023
$4.6M
NINDS NIH HHS R01 NS111166NINDS NIH HHS R01NS111166
6 · The paper itself

Abstract

objectiveThe objective of this study was to characterize the neurodevelopment and risk factors for impairment at age 5 to 6 years after acute provoked neonatal seizures.

methodsMulticenter study of neonates with acute provoked seizures. Wechsler Preschool and Primary Scale of Intelligence IV (WPPSI-IV), Vineland-3 Adaptive Behavior Scales, Behavior Assessment System for Children, Behavior Rating Inventory of Executive Function, Social Responsiveness Scale, cerebral palsy (CP), and epilepsy were assessed at age 5 to 6 years. Latent class analysis defined outcome profiles. Least absolute shrinkage and selection operator (LASSO) was used to determine outcome predictors.

resultsWe characterized 3 latent classes among 164 children: (1) Typical Development (63%); (2) Behavioral Dysregulation (13%; low likelihood of physical impairment or severely impaired cognition, high likelihood of attention deficit hyperactivity disorder [ADHD]); and (3) Multi-Domain Impairment (24%; high likelihood of epilepsy and impairment across all domains). Among 144 children with standardized testing, mean WPPSI-IV was 91 ± 25 and Vineland-3 Adaptive Behavior Composite 90 ± 20. Twenty-nine percent had ADHD or elevated attention/hyperactivity scores; 19% had autism or elevated Social Responsiveness scores; 20% had epilepsy, and 19% had CP. Risk factors for Multi-Domain Impairment were abnormal neonatal neurologic examination (odds ratio [OR] = 3.94, 95% confidence interval [CI] = 1.74-8.95), impaired functional development at age 24 months (OR = 3.82, 95% CI = 1.25-11.66), and CP (OR = 3.71, 95% CI = 1.74-7.90). No neonatal or infant characteristics were significantly associated with Behavioral Dysregulation.

interpretationNearly two-thirds of 5 to 6-year-old children with provoked neonatal seizures had typical development. Yet, executive and behavioral dysregulation were prevalent, even with preserved cognitive and physical function. These findings can inform outcome discussions and interventions to promote neurodevelopment. ANN NEUROL 2026;99:777-791.

Indexed as

Neurodevelopmental DisordersSeizuresAttention Deficit Disorder with HyperactivityCerebral PalsyChildChild, PreschoolFemaleHumansInfant, NewbornMaleRisk Factors

Identifiers

PMID41482857
PMCPMC13329800

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.