Evidence map›Paper›PMID 41482800›Full record

ArticleJournal of cellular and molecular medicine2026

Integrated Network Pharmacology, Single-Cell Transcriptomics Unveil the Mechanistic Role of Morusin in Aortic Dissection.

Zhaomeng Wang, Haoran Zhang, Zhanxiong Xie, Yukun Xiang, Yiwen Fu, Zixun Wang, Haiqing Jiao, Nan Lin, Chenguang Niu, Chao Jiang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhaomeng WangBeijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, the Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0005-6974-0511
Haoran ZhangThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Zhanxiong XieDepartment of Cardiology, Affiliated Nanping First Hospital, Fujian Medical University, Nanping, Fujian, China.
Yukun XiangBeijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, the Capital Medical University, Beijing, China.
Yiwen FuThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, China.
Zixun WangThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, China.
Haiqing JiaoSchool of Stomatology, Henan University, Kaifeng, Henan, China.
Nan LinDepartment of Cardiology, Fujian Provincial Hospital, Fuzhou, Fujian, China.
Chenguang NiuSchool of Stomatology, Henan University, Kaifeng, Henan, China.
Chao JiangDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Engineering Research Center of Medical Devices for Cardiovascular Diseases, Ministry of Education, National Clinical Research Center for Cardiovascular Diseases, Beijing, China.
Lemin ZhengThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, China.ORCID https://orcid.org/0000-0003-4473-6936

Funding

Beijing Physician Scientist Training Project BJPSTP-2024-21Henan Provincial Science and Technology Research and Development Project NO.252102311099Kaifeng Municipal Science and Technology Research and Development Project NO.2203023National High Technology Research and Development Program of China NO.2020YFA0803700National High Technology Research and Development Program of China NO. 2023YFA1800904the Natural Science Foundation of Beijing, China NO.J230039the Natural Science Foundation of Beijing, China NO.L232031
6 · The paper itself

Abstract

Aortic dissection is a life-threatening cardiovascular emergency with limited pharmacological options. This study focuses on elucidating the multi-target and multi-pathway mechanisms through which morusin mitigates aortic dissection progression, integrating network pharmacology, single-cell transcriptomics and experimental validation. Multi-database analysis identified 281 morusin targets and 1741 ad-related genes, with 84 overlaps. Enrichment analyses highlighted IL-17, HIF-1 and MAPK signalling pathways as potential regulatory hubs. Protein-protein interaction network analysis identified seven key targets, all showing high binding affinity to morusin in molecular docking. Single-cell transcriptomics revealed cell-type-specific dysregulation, notably MAPK8 upregulation in fibroblasts and immune cells. In vitro, morusin dose-dependently inhibited AngII-induced vascular smooth muscle cell proliferation and modulated IL-17 pathway gene expression. In vivo, morusin attenuated aortic dilation and reduced morbidity and mortality in a BAPN-induced AD mouse model. These findings suggest that morusin mitigates AD progression by targeting key inflammatory and apoptotic pathways, supporting its potential as a multi-target therapeutic candidate.

Indexed as

Aortic DissectionFlavonoidsNetwork PharmacologySingle-Cell AnalysisTranscriptomeAnimalsCell ProliferationDisease Models, AnimalGene Expression ProfilingGene Regulatory NetworksHumansMaleMiceMolecular Docking SimulationMyocytes, Smooth MuscleProtein Interaction MapsFlavonoidsaortic dissectionIL‐17 signalling pathwaymolecular dockingMorusinnetwork pharmacologysingle‐cell transcriptomics

Identifiers

PMID41482800
PMCPMC12759265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.