Evidence map›Paper›PMID 41482694›Full record

ArticleJournal of cosmetic dermatology2026

Development of Efficient Supramolecular Photostabilizer for Carotenoids and Retinoids: Analyses and Application Research.

Mengqing Zhao, Shuang Chen, Ke Hu, V I Evseenko, E S Meteleva, M V Zelikman, A V Dushkin, A V Mastova, M A Ulyanova, P A Kononova and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mengqing ZhaoCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.ORCID https://orcid.org/0009-0001-3679-4039
Shuang ChenCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.ORCID https://orcid.org/0009-0001-2738-5217
Ke HuZhejiang Jingxin Pharmaceutical co., Ltd., Shaoxing, China.ORCID https://orcid.org/0009-0005-5645-5615
V I EvseenkoInstitute of Solid-State Chemistry and Mechanochemistry, Novosibirsk, Russia.ORCID https://orcid.org/0000-0002-0686-3099
E S MetelevaInstitute of Solid-State Chemistry and Mechanochemistry, Novosibirsk, Russia.ORCID https://orcid.org/0000-0002-6255-5381
M V ZelikmanInstitute of Solid-State Chemistry and Mechanochemistry, Novosibirsk, Russia.ORCID https://orcid.org/0000-0001-8706-5840
A V DushkinCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.ORCID https://orcid.org/0000-0003-0269-4651
A V MastovaInstitute of Chemical Kinetics and Combustion, Novosibirsk, Russia.ORCID https://orcid.org/0000-0003-2240-6354
M A UlyanovaInstitute of Chemical Kinetics and Combustion, Novosibirsk, Russia.ORCID https://orcid.org/0009-0004-3538-3483
P A KononovaInstitute of Chemical Kinetics and Combustion, Novosibirsk, Russia.ORCID https://orcid.org/0000-0002-1956-5613
O Yu SelyutinaInstitute of Solid-State Chemistry and Mechanochemistry, Novosibirsk, Russia.ORCID https://orcid.org/0000-0003-3686-7274
Wenhao XuCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.ORCID https://orcid.org/0000-0001-7694-4268
N E PolyakovInstitute of Solid-State Chemistry and Mechanochemistry, Novosibirsk, Russia.ORCID https://orcid.org/0000-0002-3666-7750

Funding

National Key Research and Development Program of China 2021YFC2101005Russian Federal Ministry of Science and Higher Education 121032500061-7Russian Federal Ministry of Science and Higher Education FWGF-2021-0003
6 · The paper itself

Abstract

backgroundCarotenoids and retinol are well known for their potent antioxidant and biological properties in pharmaceuticals, foods, and cosmetics. However, their poor photostability presents a significant challenge that cannot be effectively addressed through simple formulation strategies such as encapsulation. Although photostabilizers are commonly employed to enhance product photostability, there remains a lack of highly water-soluble and legitimate stabilizers suitable for commercial cosmetic applications.

aimsTo develop a novel aqueous-phase photostabilizer simultaneously boosting carotenoid and retinol shelf-life in cosmetics and meeting global safety standards. Underlying mechanism and application are investigated.

methodsMicellar supramolecular complex crocin-Na

resultsExperiments demonstrated that the light-induced degradation of astaxanthin, β-carotene, and retinol in aqueous solutions, cream formulations, and on skin was significantly reduced upon the addition of crocin-Na

conclusionsCollectively, these results highlight the potential of crocin-Na

Indexed as

CarotenoidsRetinoidsAntioxidantsbeta CaroteneCosmeticsDrug StabilityHumansMicellesSkin CreamVitamin AXanthophyllsAntioxidantsastaxanthinebeta CaroteneCarotenoidsCosmeticscrocinMicellesRetinoidsVitamin AXanthophyllscarotenoidscrocinglycyrrhizinmixed micellesphoto‐protectionphotostabilizerretinol

Identifiers

PMID41482694
PMCPMC12759200

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.