ArticleJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2026
Skin lesion triage in organ transplant recipients using line-field confocal optical coherence tomography: a retrospective classification study.
Article in Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The Role of RCM and LC-OCT in Genodermatoses Associated with Skin Cancer: A Narrative Review.Acta dermato-venereologica · 2026Review
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5 authors.
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Abstract
BACKGROUND/
objectivesOrgan transplant recipients (OTRs) face an elevated risk of keratinocyte carcinomas (KC), leading to a lower threshold for biopsy. Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive imaging technique capable of visualizing malignant skin changes, yet its role in the management of OTRs remains unexplored. The objective was to investigate the potential of LC-OCT for triage of skin lesions in OTRs. PATIENTS AND
methodsClinically equivocal lesions in OTRs (n = 75) were scanned using LC-OCT before biopsy. Scans were assessed retrospectively for predefined LC-OCT criteria (i.e., image-markers) for KC and premalignant/in-situ lesions (Bowen's disease and actinic keratosis). The most high-yield criteria were identified and combined into a decision-tree.
resultsA 4-step decision-tree for lesion triage with five LC-OCT criteria was developed, with a sensitivity of 87.5 % for squamous cell carcinoma (n = 8), 94.4 % for basal cell carcinoma (n = 18), 83.3 % for Bowen's disease (n = 12), and 72.7 % for actinic keratosis (n = 22). This triage is based on severe dysplasia, broad strands and keratin pearls for SCC, lobules for BCC, and severe or mild-moderate dysplasia for premalignant lesions.
conclusionsThis study designed an LC-OCT decision-tree for use in immunocompromised patients to assist in triage of equivocal skin lesions with potential for improving clinical-decision making.
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