Evidence map›Paper›PMID 41482662›Full record

ArticleJournal of cellular and molecular medicine2026

Comparative Investigation of Cytotoxic Effects of Structurally Diverse Small Molecules and In Silico Analysis of 1-Acetyl-4-(4-Hydroxyphenyl)piperazine.

Azmi Yerlikaya, Emrah Tümer, Mustafa Güzel

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Azmi YerlikayaDepartment of Medical Biology, Faculty of Medicine, Kutahya Health Sciences University, Kutahya, Turkey.ORCID https://orcid.org/0000-0002-0678-0701
Emrah TümerDepartment of Medical Biology, Faculty of Medicine, Kutahya Health Sciences University, Kutahya, Turkey.ORCID https://orcid.org/0000-0002-2198-9386
Mustafa GüzelResearch Institute for Health Sciences and Technologies (SABITA), Center of Drug Discovery and Development, İstanbul Medipol University, Istanbul, Turkiye.ORCID https://orcid.org/0000-0002-1423-0435

Funding

The Scientific and Technological Research Council of Türkiye (TÜBİTAK) 119S224
6 · The paper itself

Abstract

This study assessed the anticancer activity of boron-containing and structurally diverse small molecules in 4T1 breast cancer and Caco-2 colon adenocarcinoma cells. Initial screening showed that five boronic acids lacked significant cytotoxicity, underscoring the structural specificity required for boron-mediated bioactivity. Similarly, reference compounds, including fumaric acid, caffeic acid, ferulic acid, dimethyl malonate and N-(tert-butoxycarbonyl)-L-alanine, showed no cytotoxic effect under identical conditions. Among the tested agents, 1-acetyl-4-(4-hydroxyphenyl)piperazine (1A4HP) displayed the most potent cytotoxicity, with IC

Indexed as

Antineoplastic AgentsPiperazinesSmall Molecule LibrariesAnimalsApoptosisBreast NeoplasmsCaco-2 CellsCell Line, TumorCell MovementCell ProliferationComputer SimulationEstrogen Receptor alphaFemaleHumansMiceMolecular Docking SimulationAntineoplastic AgentsEstrogen Receptor alphaPiperazinePiperazinesSmall Molecule Libraries1‐acetyl‐4‐(4‐hydroxyphenyl)piperazineboronic acidsbreast cancercolon cancercytotoxicity

Identifiers

PMID41482662
PMCPMC12759113

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.