ArticleNature immunology2026
Skin-derived myeloid precursors and joint-resident fibroblasts spread psoriatic disease from skin to joints.
Abstract read
In one paragraph
Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of Biologic Therapies on the Risk of Progression from Psoriasis to Psoriatic Arthritis: A Systematic Review and Meta-Analysis of Cohort Studies.American journal of clinical dermatology · 2026Pooled it
- From psoriatic plaque to synovium: decoding the skin-joint axis in psoriatic arthritis.Nature reviews. Rheumatology · 2026Review
- [Psoriatic arthritis as MHC-I-associated disease].Zeitschrift fur Rheumatologie · 2026Review
- Effect of apremilast on entheseal bone damage in psoriasis patients at risk of developing psoriatic arthritis - data from the prospective, interventional EPOS study.Arthritis research & therapy · 2026Article
- Arthritis susceptibility begins before birth.Nature immunology · 2026Article
- Does effective therapy of psoriasis prevent the development of psoriatic arthritis?EULAR rheumatology open · 2026Review
- Spreading inflammation via the skin-joint axis.Nature reviews. Immunology · 2026Article
- Psoriasis as a systemic inflammatory disease: an immune set-point framework for comorbidities and relapse.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors.
Maria G Raimondo *Department of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.ORCID 0000-0003-2020-6711
Hashem Mohammadian *Department of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.ORCID 0000-0003-2565-2702
Mario R AngeliDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.ORCID 0000-0002-2911-4269
Stefano AliverniniDivision of Rheumatology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.ORCID 0000-0002-7383-4212
Vladyslav FedorchenkoDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.
Kaiyue HuangDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.
Richard DemmlerDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.
Peter RheinApplications, Cytek Biosciences, Amsterdam, the Netherlands.
Cong XuDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.
Yi-Nan LiClinic for Rheumatology, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0001-8934-9361
Raphael MicheroliCenter of Experimental Rheumatology, Department of Rheumatology, University Hospital of Zurich and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-8918-7304
Zoltán WinterInstitute of Radiology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.ORCID 0000-0003-4119-9637
Aleix Rius RigauDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.
Charles G AnchangDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.
Alina SoareDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.
Markus LuberDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.ORCID 0000-0003-1895-5481
Hannah LabinskyDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.
Jiyang ChangDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.
Claudia GüntherDepartment of Dermatology, University Hospital Carl Gustav Carus Dresden and TU Dresden, Dresden, Germany.
Ursula FearonMolecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Douglas J VealeEULAR Centre of Excellence for Rheumatology, Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital, Dublin, Ireland.ORCID 0000-0003-2802-4971
Francesco CicciaDepartment of Precision Medicine, Division of Rheumatology, Università della Campania L. Vanvitelli, Naples, Italy.ORCID 0000-0002-9352-1264
Jürgen RechDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.ORCID 0000-0002-2569-2029
Michael SticherlingDeutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.
Tobias BäuerleInstitute of Radiology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.
Jörg H W DistlerClinic for Rheumatology, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Mariola S Kurowska-StolarskaResearch into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Glasgow, Glasgow, UK.ORCID 0000-0003-2124-7777
Matthias MackDepartment of Nephrology, University Hospital Regensburg and University of Regensburg, Regensburg, Germany.ORCID 0000-0002-3157-7262
Arif B EkiciInstitute of Human Genetics, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.ORCID 0000-0001-6099-7066
Adam P CroftRheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0002-9487-0511
Oliver DistlerCenter of Experimental Rheumatology, Department of Rheumatology, University Hospital of Zurich and University of Zurich, Zurich, Switzerland.
Hans M MaricRudolf-Virchow-Center for Integrative and Translational Imaging, University of Würzburg, Würzburg, Germany.ORCID 0000-0002-2719-4752
Caroline OspeltCenter of Experimental Rheumatology, Department of Rheumatology, University Hospital of Zurich and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-9151-4650
Juan D CañeteDepartment of Rheumatology, Hospital Clínic of Barcelona and Fundació Clinic per la Recerca Biomèdica-IDIBAPS, Barcelona, Spain.ORCID 0000-0003-2606-0573
Maria A D'AgostinoDivision of Rheumatology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Georg SchettDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.ORCID 0000-0001-8740-9615
Simon RauberDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.ORCID 0000-0001-8306-9334
Andreas RammingDepartment of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany. andreas.ramming@uk-erlangen.de.ORCID 0000-0002-7003-501X
Funding
Deutsche Forschungsgemeinschaft (German Research Foundation) 261193037Deutsche Forschungsgemeinschaft (German Research Foundation) 391371888Deutsche Forschungsgemeinschaft (German Research Foundation) 424726560Deutsche Forschungsgemeinschaft (German Research Foundation) 456565718Deutsche Forschungsgemeinschaft (German Research Foundation) 493624887Deutsche Forschungsgemeinschaft (German Research Foundation) RA 2506/7-1 and 493624887Deutsche Forschungsgemeinschaft (German Research Foundation) SO 1735/2-1EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 810316EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 853508
Abstract
Psoriatic disease initially affects the skin and later extends to the joints. Here, we show a two-step process that orchestrates the spread of inflammation from the skin to the joints. Induction of psoriatic skin disease in photoconvertible mice, followed by sequencing and computational characterization of skin-derived cells in the joints, was used to identify a population of CD2
Indexed as
FibroblastsJointsMyeloid Progenitor CellsPsoriasisSkinAnimalsCell MovementDisease Models, AnimalHumansInterleukin-17MiceMyeloid CellsT-LymphocytesInterleukin-17
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.