Evidence map›Paper›PMID 41482519›Full record

ArticleNature aging2026

Shear stress governs hematopoietic stem cell fate to promote inflammation-induced aging.

Tongyao Shang, Li Zhao, Shibo Ying, Lida Su, Yue Yang, Jiadong Liu, Yingying Wang, Jipeng Xue, Cheng Cheng, Yixin Wu and 10 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Improving lymphopoiesis in aged bone marrow.Current opinion in hematology · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Tongyao Shang *Department of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Li Zhao *School of Civil Engineering and Architecture, Zhejiang University of Science & Technology, Hangzhou, China.
Shibo Ying *Hangzhou Medical College, Hangzhou, China.
Lida SuNeuroscience Care Unit, Key Laboratory of Multiple Organ Failure of Ministry of Education, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yue YangDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jiadong LiuDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yingying WangDepartment of Biophysics and Neurology, Center for Membrane Receptors and Brain Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Jipeng XueDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Cheng ChengDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yixin WuDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Shiyao ChenDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hongmei DongThe 941st Hospital of Joint Logistics Support Force of PLA, Xining, China.
Xuequn ChenDepartment of Neurology of Second Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China.
Hailin MaKey Laboratory of High Altitudes Brain Science and Environmental Acclimation, Xizang University, Lhasa, China.
Qi ZhangDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID http://orcid.org/0000-0002-6096-0690
Tingbo LiangDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID http://orcid.org/0000-0003-0143-3353
Wei YangDepartment of Biophysics and Neurology, Center for Membrane Receptors and Brain Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China. yangwei@zju.edu.cn.ORCID http://orcid.org/0000-0003-3065-1843
Ye FengInstitute of Translational Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. pandafengye@zju.edu.cn.ORCID http://orcid.org/0000-0002-6551-1560
Marong FangOrthopedics Department, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Centre for Child Health, Hangzhou, China. fangmaro@zju.edu.cn.ORCID http://orcid.org/0000-0002-6636-4347
Xinjiang LuDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. luxinjiang@zju.edu.cn.ORCID http://orcid.org/0000-0002-7796-4401

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32120103007National Natural Science Foundation of China (National Science Foundation of China) 82072241National Natural Science Foundation of China (National Science Foundation of China) 82471905Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) LZ23C110001
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) reside in the bone marrow in a quiescent state, but can be mobilized into the blood in response to inflammation, cytokine stimulation, nervous activity or hypoxia. Chronic inflammation, a hallmark of aging, accelerates HSC aging by promoting myeloid-biased differentiation and reducing self-renewal capacity, yet the role of mechanical stimulation in regulating these processes remains poorly understood. Here, we found that PIEZO1 senses shear stress in blood flow to induce HSC proliferation and myelopoiesis. We show that shear stress induces PIEZO1-mediated ion currents and Ca

Indexed as

AgingHematopoietic Stem CellsInflammationIon ChannelsStress, MechanicalAnimalsCalciumCell DifferentiationCell ProliferationHumansIntercellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLMyelopoiesisSpider VenomsCalciumIntercellular Signaling Peptides and ProteinsIon ChannelsMTx4 protein, Grammostola spatulataPIEZO1 protein, humanPiezo1 protein, mouseSpider Venoms

Identifiers

PMID41482519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.