ArticleJournal of applied clinical medical physics2026
Organ-specific low-dose assessment in pediatric radiotherapy using nanodot OSL and NTCP modeling: Application to medulloblastoma.
Article in Journal of applied clinical medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Organ-specific low-dose assessment in pediatric radiotherapy using nanodot OSL and NTCP modeling: Application to medulloblastoma.Journal of applied clinical medical physics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn pediatric radiotherapy, controlling low-dose exposure is a major challenge, particularly in the treatment of medulloblastoma, where the long life expectancy of young patients makes optimization of radioprotection crucial. PURPOSE: This study provides a comprehensive and quantitative assessment of low-dose exposure to normal tissues across the entire radiotherapy workflow, with a particular emphasis on the contribution of imaging procedures (planning computed tomography (CT) and repeated cone beam computed tomography (CBCT) acquisitions) in addition to therapeutic irradiation. The cumulative impact of these steps is evaluated together with the associated risks using Normal Tissue Complication Probability (NTCP) modeling.
methodsA pediatric anthropomorphic phantom was equipped with optically stimulated luminescence (OSL) dosimeters to measure doses delivered to normal organs during the planning CT, 15 CBCT scans for positioning, and simulated treatment plans with different radiotherapy techniques. NTCPs were calculated for critical organs based on the dosimetric data from imaging and treatment planning.
resultsEach imaging acquisition delivered between 3 and 7 mGy per organ, with the cumulative dose from CT and CBCT remaining consistently below 0.5 Gy, representing less than 1% of the prescribed therapeutic dose. Although small compared to therapeutic irradiation, this contribution remains biologically relevant when considering cumulative low-dose exposure in pediatric patients. Dosimetric comparison of treatment techniques showed that volumetric modulated arc therapy (VMAT) significantly reduced both the mean organ dose and the NTCP compared to three-dimensional conformal radiation therapy (3D-CRT): heart dose decreased from 16 Gy (NTCP 30%) to 6.6 Gy (NTCP 0.4%), and thyroid dose from 27.1 Gy (NTCP 12%) to 8.7 Gy (NTCP < 1%). Some organs, such as the brain and chiasma, remained highly exposed, reflecting the dosimetric constraints of comprehensive tumor coverage.
conclusionBy systematically quantifying and integrating imaging doses with therapeutic irradiation, this study underscores the often underestimated role of imaging in cumulative exposure during pediatric craniospinal irradiation. The results provide a solid foundation for tailoring radioprotection strategies and emphasize the need to reconsider planning and follow-up protocols to deliver safer and more targeted treatments for children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.