ArticleIn vivo (Athens, Greece)
Refined Surgical Protocol for the Insertion of Bioactive-coated Titanium Microscrews in the Rat Tibia.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Composite Coating-driven Regulation ofIn vivo (Athens, Greece)Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimSensitive bioactive coatings, such as polycaprolactone with cholecalciferol, present handling challenges in animal models due to their susceptibility to mechanical damage. This study aimed to develop and validate a refined surgical protocol for inserting such polycaprolactone-cholecalciferol-coated titanium microscrews into the proximal tibia of Sprague-Dawley rats, ensuring primary stability and preserving the integrity of the nanofibrous coating. MATERIALS AND
methodsFourteen male Sprague-Dawley rats (300-350 g) were used: one pilot and 13 animals in the main trial. A 3D anatomical tibia model was created for
resultsThe refined protocol achieved 100% procedural success. All implants reached immediate primary stability with uneventful first-intention healing and no critical adverse events. SEM confirmed preservation of morphology of the nanofibrous coating exclusively in the refined protocol group. Micro-computed tomography demonstrated consistent bone-to-implant contact in both cortical and trabecular compartments. Clinical recovery was rapid and spontaneous, with all animals maintaining optimal welfare indicators throughout follow-up.
conclusionThe refined protocol safeguards the structural integrity of functionalized surfaces, ensures primary stability, and promotes early osseointegration, while complying with the principles of replacement, reduction, and refinement (3Rs). This model provides a valid experimental platform for investigations into osseointegration dynamics and the controlled local release of therapeutic agents.
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