ArticleIn vivo (Athens, Greece)
Establishment of a Step-down FSH Superovulation Protocol in Microminipigs for Zygote Collection.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
aimDomestic pigs have become increasingly important models in translational research; however, their large size presents logistical and ethical challenges. Microminipigs offer a practical alternative for long-term studies. This study aimed to develop an effective superovulation protocol using a step-down follicle-stimulating hormone (FSH) regimen to improve zygote collection in microminipigs. MATERIALS AND
methodsIn experiment 1, four female microminipigs with regular estrous cycles were used in both the control and treatment conditions in a crossover design. Treatment group was received prostaglandin F2α (PGF
resultsOn day 0, the number of follicles was higher in the treatment group (93.0±7.74) compared to the control (46.8±5.01). Significant differences were observed on days -1 and 0, while by day+1, the number of follicles decreased in both groups. Follicle area was significantly larger in the treatment than in the control group (0.81±0.03 cm
conclusionThe step-down FSH protocol effectively enhanced ovarian response and embryo yield in microminipigs, marking a foundational step toward the efficient reproductive engineering for this animal model that may contribute to the advancement of translational research.
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