ArticleIn vivo (Athens, Greece)
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8 authors.
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Abstract
BACKGROUND/
aimAutologous platelet-derived growth factors such as platelet rich fibrin (PRF) are receiving increasing attention in the context of different medical situations such as soft-tissue wound healing or bone regeneration in patients with cancer suffering from therapy-associated osteonecrosis. PRF has been observed to support the colonization and differentiation of osteoblasts, thereby improving the wound healing process. In the recent past, fruit extracts from the tropical plant MATERIALS AND
methodsForty healthy volunteers participated in a prospective, single-blinded, placebo-controlled, cross-over study. Participants consumed either noni juice (2 ml/kg/day) or placebo for four weeks, separated by a four-week washout. Blood samples were collected, and PRF was prepared by centrifugation. Clinical blood values were analyzed, and PRF samples were examined for growth factors, structural proteins, and cytokines using ELISA and cytokine arrays.
resultsNoni juice consumption led to significant changes in blood calcium, ALAT, and γ-GT levels. PRF analysis revealed elevated interleukin-11 (IL-11), macrophage colony-stimulating factor (M-CSF), and chemokine CCL7, indicating that noni juice alters the molecular profile of PRF.
conclusionRegular intake of noni juice influences PRF composition and modulates hepatic enzymes. These findings highlight the potential of dietary factors to impact regenerative biomaterials and warrant further targeted investigations.
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