ArticleIn vivo (Athens, Greece)
Development of a Universal Electric Medical Clamp for Rotational Intraperitoneal Aerosol Chemotherapy.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimPeritoneal metastasis is associated with poor prognosis and low response rates to systemic chemotherapy due to multidrug resistance. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has improved local drug delivery but remains limited by uneven drug distribution, with most aerosol deposition concentrated opposite the nozzle. To overcome this, rotational intraperitoneal aerosol chemotherapy (RIPAC) was developed. This study aimed to design a universal electric medical clamp enabling stable nozzle rotation for RIPAC. MATERIALS AND
methodsA prototype device was constructed using a miniaturized electric motor mounted within a modular clamp to induce conical pendulum motion of the aerosol nozzle. Iterative design optimizations addressed instability and vibration, evolving from simple fixed joints to reinforced mechanical assemblies and finally a hydraulic joint system. Prototypes were evaluated in benchtop and porcine models for motion stability, spray uniformity, and mechanical robustness under operative conditions.
resultsThe initial mockup device achieved pendulum-like motion but failed to maintain stability during
conclusionA universal electric medical clamp was successfully developed for RIPAC, providing stable rotational motion and improved drug distribution potential compared with PIPAC. This innovation lays the groundwork for clinical translation of RIPAC as a promising strategy to enhance intraperitoneal chemotherapy efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.