Evidence map›Paper›PMID 41482382›Full record

SynthesisIn vivo (Athens, Greece)

Slow-release L-cysteine Lozenges in Smoking Cessation: Meta-analysis of Two Randomized Controlled Trials.

Kari Syrjänen, Osmo Suovaniemi

Abstract readMeta-Analysis
In one paragraph

Synthesis in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kari SyrjänenDepartment of Clinical Research, Biohit Oyj, Helsinki, Finland; kasyrja@saunalahti.fi.
Osmo SuovaniemiDepartment of Clinical Research, Biohit Oyj, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThe hypothesis that elimination of cigarette smoke-derived acetaldehyde in the saliva by slow-release L-cysteine would eliminate acetaldehyde-enhanced nicotine addiction among smokers has been tested in two randomized controlled trials (RCT) using Acetium MATERIALS AND

methodsThe two published RCTs on Acetium

resultsIn the ITT group of Study 1, Acetium

conclusionAlthough meta-analyses with a limited number of studies should be interpreted with caution, these data provide clear support to the concept that Acetium

Indexed as

CysteineSmoking CessationDelayed-Action PreparationsHumansRandomized Controlled Trials as TopicTreatment OutcomeCysteineDelayed-Action Preparationslozengemeta-analysisrandomized controlled trialreviewslow-release L-cysteineSmoking intervention

Identifiers

PMID41482382
PMCPMC12764195

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.