ArticleIn vivo (Athens, Greece)
The Protective Effect of Decellularized Extracellular Matrix in Osteoarthritis: An
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
BACKGROUND/
aimOsteoarthritis (OA) is a degenerative joint disease affecting both humans and companion animals, characterized by progressive cartilage destruction, inflammation, and functional impairment. Current therapies provide mainly symptomatic relief, emphasizing the need for regenerative strategies. Decellularized extracellular matrix (dECM) hydrogels preserve native biochemical cues and biocompatibility, making them potential candidates for cartilage protection and regeneration. This study aimed to evaluate the biocompatibility, anti-inflammatory activity, and chondroprotective potential of meniscus-derived dECM (Meni-dECM) hydrogel. MATERIALS AND
methodsMeniscus tissue was decellularized and processed into hydrogel form.
results
conclusionMeni-dECM hydrogels demonstrated protective effects against OA progression by modulating inflammation and preserving cartilage architecture. These findings support Meni-dECM hydrogel as a promising injectable biomaterial for OA management in both veterinary and translational medicine. Further studies are warranted to confirm long-term stability, elucidate molecular mechanisms, and evaluate clinical feasibility.
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