Evidence map›Paper›PMID 41482373›Full record

ArticleIn vivo (Athens, Greece)

Modulating

Johanna R Rusche, Michael Bette, Boris A Stuck, Udo Bakowsky, Urban W Geisthoff, Robert Mandic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Johanna R RuscheVASCERN HHT Reference Center and Interdisciplinary Center for Vascular Anomalies, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Giessen and Marburg, Campus Marburg, and Philipps-Universität Marburg, Marburg, Germany.
Michael BetteDepartment of Molecular Neuroscience, Institute of Anatomy and Cell Biology, Philipps-Universität Marburg, Marburg, Germany.
Boris A StuckVASCERN HHT Reference Center and Interdisciplinary Center for Vascular Anomalies, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Giessen and Marburg, Campus Marburg, and Philipps-Universität Marburg, Marburg, Germany.
Udo BakowskyDepartment of Pharmaceutics and Biopharmaceutics, Philipps-Universität Marburg, Marburg, Germany.
Urban W GeisthoffVASCERN HHT Reference Center and Interdisciplinary Center for Vascular Anomalies, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Giessen and Marburg, Campus Marburg, and Philipps-Universität Marburg, Marburg, Germany.
Robert MandicVASCERN HHT Reference Center and Interdisciplinary Center for Vascular Anomalies, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Giessen and Marburg, Campus Marburg, and Philipps-Universität Marburg, Marburg, Germany; mandic@med.uni-marburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimHereditary hemorrhagic telangiectasia (HHT) is a rare disease with an incidence of 1:5,000. HHT is inherited in an autosomal dominant manner and is associated with vascular malformations. It particularly affects the genes MATERIALS AND

methodsThe human immortalized endothelial cell line HMEC-1 was used for the experiments. RNAi knockdown was performed using a pool of four siRNAs targeting the

resultsTube formation ability was significantly affected by

conclusionKnockdown of

Indexed as

Activin Receptors, Type IIEndothelial CellsGene Expression RegulationTelangiectasia, Hereditary HemorrhagicCell LineGene Knockdown TechniquesHumansRNA, Small InterferingActivin Receptors, Type IIACVRL1 protein, humanRNA, Small InterferingACVRL1HHT2HMEC-1in vitro modelRNAi

Identifiers

PMID41482373
PMCPMC12764187

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.