ArticleIn vivo (Athens, Greece)
Risk Factors of Mortality in Older Patients With Candidemia.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Persistent Non-Journal of fungi (Basel, Switzerland) · 2026Article
- Impact of COVID-19 and earthquake disaster on candidemia in the ICU: mortality and treatment outcomes.BMC infectious diseases · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimCandidemia is a life-threatening fungal infection associated with high mortality and significant morbidity, particularly among older adults. Few studies have addressed mortality in this population. This study aimed to identify the risk factors for mortality in older patients with candidemia. PATIENTS AND
methodsWe conducted a retrospective study to identify the risk factors for mortality in older patients with candidemia using the Medical Information Mart for Intensive Care-IV database. The clinical characteristics and risk factors for mortality in patients younger or older than 65 years of age were determined. We also evaluated the effects of early antifungal therapy on outcomes in these patients.
resultsAmong patients with candidemia, advanced age, congestive heart failure, cardiac arrhythmia, smoking habits, leukocytosis, and thrombocytopenia were significantly associated with in-hospital mortality. The early administration of antifungal therapy was related to improved survival in all age groups. Among older individuals who died during hospitalization, a higher prevalence of congestive heart failure, pulmonary vascular diseases, and smoking habit was observed. In contrast, the younger patients who died had a higher incidence of underlying metastatic cancer, coagulopathy, and cardiac arrhythmia.
conclusionOlder patients with candidemia had higher in-hospital mortality rates than those of younger patients. Thrombocytopenia was found to be an independent risk factor, and early fungal therapy was associated with lower in-hospital mortality. Early identification of patients with candidemia and appropriate antifungal therapy are important for its treatment.
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