ArticleIn vivo (Athens, Greece)
Increased Expression of
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimCancer cachexia is a complication that emerges in approximately 50-80% of patients with advanced cancer, characterized by symptoms such as lipoatrophy, skeletal muscle loss, metabolic abnormalities, and anorexia. While UCP1, a mitochondrial uncoupling protein, is implicated in lipolysis associated with cancer cachexia, the involvement of other thermogenic proteins remains unclear. In this exploratory study, we examined the expression of thermogenic genes in a mouse model of cancer cachexia. MATERIALS AND
methodsTumor-bearing mice were generated by injecting Colon-26 cells (C26) into the right flank of male BALB/c mice. The body weight and temperature, tumor volume, and food intake of these mice were recorded three times a week. After 46 days of C26 administration, the adipose tissue, muscle, tumor, and blood were isolated from the mice and analyzed for thermogenic gene expression and biochemical parameters.
resultsQuantitative reverse transcription PCR analysis revealed increased expression of
conclusionAlthough the functional relevance of
Indexed as
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