Evidence map›Paper›PMID 41482356›Full record

ArticleCancer genomics & proteomics

RUNX2 Represses the EWS-FLI1-mediated Transcription in Ewing's Sarcoma Cells.

Takao Kitagawa, Byron Baron, Hajime Okita, Junichi Hamada, Koji Nakagawa, Masanobu Kobayashi, Tohru Ohta, Yasuhiro Kuramitsu

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In one paragraph

Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Takao KitagawaAdvanced Research Promotion Center, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan; takao-k@hoku-iryo-u.ac.jp.
Byron BaronCenter for Molecular Medicine and Biobanking, University of Malta, Msida, Malta.
Hajime OkitaDepartment of Diagnostic Pathology, National Cancer Center Hospital, Chuo-ku, Japan.
Junichi HamadaAdvanced Research Promotion Center, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
Koji NakagawaAdvanced Research Promotion Center, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
Masanobu KobayashiAdvanced Research Promotion Center, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
Tohru OhtaAdvanced Research Promotion Center, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
Yasuhiro KuramitsuAdvanced Research Promotion Center, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimEwing's sarcoma is an aggressive pediatric malignancy driven by specific chromosomal translocations, predominantly leading to the oncogenic fusion protein EWS-FLI1. Runt-related transcription factors 1 and 2 (RUNX1 and RUNX2), which are key transcription factors involved in osteoblastic differentiation and skeletal morphogenesis, are not expressed in Ewing's sarcoma. Our study aimed to elucidate the relationship between the MATERIALS AND

methodsWe used Ewing's sarcoma cell lines (A673 and NCR-EW2). EWS-FLI1 knockdown was achieved using shRNA, while inducible expression of

resultsWe observed low expression of RUNX1 and RUNX2 in Ewing's sarcoma cells. Notably, EWS-FLI1 knockdown increased

conclusionEWS-FLI1 suppresses

Indexed as

Bone NeoplasmsCore Binding Factor Alpha 1 SubunitCore Binding Factor Alpha 2 SubunitOncogene Proteins, FusionProto-Oncogene Protein c-fli-1RNA-Binding Protein EWSSarcoma, EwingCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansTranscription, GeneticCore Binding Factor Alpha 1 SubunitCore Binding Factor Alpha 2 SubunitEWS-FLI fusion proteinOncogene Proteins, FusionProto-Oncogene Protein c-fli-1RNA-Binding Protein EWSRUNX1 protein, humanRUNX2 protein, humanEwing’s sarcomaEWS-ERGEWS-FLI1RUNX1RUNX2

Identifiers

PMID41482356
PMCPMC12758659

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.