Evidence map›Paper›PMID 41482351›Full record

ArticleCancer genomics & proteomics

Mechanistic Insights into Threonine Tyrosine Kinase Mediated Cell Cycle Regulation in Triple-negative Breast Cancer.

Siya Tang, Jiayu Zheng, Yalin Zhang, L I Zeng, Jingjing Wang, Shunshun Zhang, Youyou Chen, Qinan Yin, Xuewei Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siya Tang *Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, P.R. China.
Jiayu Zheng *Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, P.R. China.
Yalin ZhangPrecision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, P.R. China.
L I ZengPrecision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, P.R. China.
Jingjing WangPrecision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, P.R. China.
Shunshun ZhangPrecision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, P.R. China.
Youyou ChenPrecision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, P.R. China.
Qinan YinPrecision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, P.R. China; qinanyin@haust.edu.cn.
Xuewei ZhengPrecision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, P.R. China; xwzheng0529@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimTriple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking targeted therapies, characterized by high heterogeneity and poor prognosis. Dysregulated cell cycle progression and aberrant Wnt/β-catenin signaling are critical drivers of TNBC proliferation. This study aimed to advance understanding of TTK driven oncogenesis and assess its promise as a prognostic biomarker and therapeutic target in TNBC. MATERIALS AND

methodsWe analyzed bulk and single-cell RNA sequencing datasets to assess TTK expression and clinical relevance in breast cancer. TNBC cell lines and normal breast epithelial cells were used for

resultsTTK was overexpressed in breast tumors

conclusionTTK drives TNBC progression by orchestrating G

Indexed as

Cell Cycle ProteinsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesTriple Negative Breast Neoplasmsbeta CateninBiomarkers, TumorCell CycleCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansPrognosisWnt Signaling Pathwaybeta CateninBiomarkers, TumorCell Cycle ProteinsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesTTK protein, humancell cycle regulationprognostic biomarkerTriple-negative breast cancerTTKβ-catenin signaling

Identifiers

PMID41482351
PMCPMC12758666

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.